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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Chikungunya virus adapts to tiger mosquito via evolutionary convergence: A sign of things to come?
Virology Journal, Volume 5, Article 33, Year 2008
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Description
Since 2004, several million indigenous cases of Chikungunya virus disease occurred in Africa, the Indian Ocean, India, Asia and, recently, Europe. The virus, usually transmitted by Aedes aegypti mosquitoes, has now repeatedly been associated with a new vector, Ae. Albopictus. Analysis of full-length viral sequences reveals three independent events of virus exposure to Ae. Albopictus, each followed by the acquisition of a single adaptive mutation providing selective advantage for transmission by this mosquito. This disconcerting and current unique example of "evolutionary convergence" occurring in nature illustrates rapid pathogen adaptation to ecological perturbation, driven directly as a consequence of human activities. © 2008 de Lamballerie et al; licensee BioMed Central Ltd.
Authors & Co-Authors
De-Lamballerie, Xavier Nicolas
France, Marseille
Aix Marseille Université
Leroy, Éric Maurice
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Charrel, Remi N.
France, Marseille
Aix Marseille Université
Ttsetsarkin, Konstantin
United States, Galveston
University of Texas Medical Branch, School of Medicine
Higgs, Stephen T.
United States, Galveston
University of Texas Medical Branch, School of Medicine
Gould, Ernest Andrew
France, Marseille
Aix Marseille Université
Statistics
Citations: 307
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1186/1743-422X-5-33
e-ISSN:
1743422X
Research Areas
Cancer