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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
In search of susceptibility genes for type 2 diabetes in West Africa: The design and results of the first phase of the AADM study
Annals of Epidemiology, Volume 11, No. 1, Year 2001
Notification
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Description
PURPOSE: The purpose of this study is to map type 2 diabetes susceptibility genes in West African ancestral populations of African-Americans, through an international collaboration between West African and US investigators. DESIGN AND METHODS: Affected sib-pairs (ASP) along with unaffected spouse controls are being enrolled and examined in West Africa, with two sites established in Ghana (Accra and Kumasi) and three in Nigeria (Enugu, Ibadan, and Lagos). Eligible participants are invited to study clinics to obtain detailed epidemiologic, family, and medical history information. Blood samples are drawn from each participant to measure glucose, insulin, C-peptide, total cholesterol, LDL, HDL, triglycerides, albumin, creatinine, urea, uric acid, total calcium and to detect autoantibodies to glutamic acid decarboxylase (GAD). DNA is isolated from frozen white blood cells obtained from 20 ml of EDTA whole blood samples. RESULTS: With full informed consent, 162 individuals from 78 families have been enrolled and examined since the Africa America Diabetes Mellitus (AADM) study began in June of 1997. Logistics of field examinations and specimen shipping have been successfully established. At the end of the third year of field activity (September 2000) the AADM study will have enrolled and performed comprehensive examination on 400 ASP with type 2 diabetes, for a minimum of 800 cases and 200 controls from Ghana and Nigeria. At the current participation rate, the goal of 400 sib-pairs and 200 controls will be met before the scheduled closing date. CONCLUSIONS: The AADM study will create a comprehensive epidemiologic and genetic resource that will facilitate a powerful genome-wide search for West African susceptibility genes to type 2 diabetes. Copyright © 2000 Elsevier Science Inc.
Authors & Co-Authors
Rotimi, Charles N.
Unknown Affiliation
Dunston, Georgia M.
Unknown Affiliation
Berg, Kate A.
Unknown Affiliation
Akinsete, Omobosola
Unknown Affiliation
Amoah, Albert George Baidoe
Unknown Affiliation
Owusu, Samuel K.
Unknown Affiliation
Acheampong, Joseph W.
Unknown Affiliation
Boateng, Kofi A.
Unknown Affiliation
Oli, Johnnie M.
Unknown Affiliation
Okafor, Godfrey O.
Unknown Affiliation
Onyenekwe, Belonwu M.
Unknown Affiliation
Osotimehin, Babatunde O.
Unknown Affiliation
Abbiyesuku, Fayeofori Mpakabaori
Unknown Affiliation
Johnson, Thomas Osotayo
Unknown Affiliation
Fasanmade, Olufemi Adetola
Unknown Affiliation
Furbert-Harris, Paulette
Unknown Affiliation
Kittles, Rick A.
Unknown Affiliation
Vekich, Mirjana
Unknown Affiliation
Adegoke, Olufemi J.
Unknown Affiliation
Bonney, George
Unknown Affiliation
Collins, Francis S.
Unknown Affiliation
Statistics
Citations: 88
Authors: 21
Affiliations: 9
Identifiers
Doi:
10.1016/S1047-2797(00)00180-0
ISSN:
10472797
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Locations
Multi-countries
Ghana
Nigeria