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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Aerobic exercises enhance cognitive functions and brain derived neurotrophic factor in ischemic stroke patients
NeuroRehabilitation, Volume 34, No. 1, Year 2014
Notification
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Description
BACKGROUND: Stroke is a leading cause of functional impairments. High percentage of these patients will experience some degree of cognitive affection, ranging from mild cognitive impairment to dementia. OBJECTIVE: Demonstrate the role of aerobic exercises enhancing cognitive functions and its effect on Brain Derived Neurotrophic factor (BDNF) in post-ischemic stroke patients in the territory of anterior circulation. SUBJECTS AND METHODS: We included thirty Egyptian ischemic stroke patients in the territory of anterior circulation. They were divided into 2 groups; group 1 (G1) were subjected to physiotherapy program without aerobic exercises and group 2 (G2) were subjected to the same previous program followed by aerobic exercises. Both groups were subjected to pre-and post-treatment Addenbrookes's Cognitive Examination-Revised (ACER) and serum level of BDNF. RESULTS: Our results showed a significant improvement in ACER score in G2 compared to G1 post-treatment (p = 0.017). BDNF serum level significantly increased in G2 post-treatment compared to pre-treatment (p = 0.001) and compared to G1 group (p = 0.0458). ACER improvement was positively correlated to increase in serum level of BDNF (r = 0.53, p = 0.044). CONCLUSION: Aerobic exercises improve cognitive functions of ischemic stroke patients. This improvement is related to the increase in serum level of BDNF. © 2014-IOS Press and the authors. All rights reserved.
Authors & Co-Authors
El-Tamawy, Mohamed Soliman
Egypt, Cairo
Faculty of Medicine
Abd-Allah, Foad
Egypt, Cairo
Faculty of Medicine
Ahmed, Sandra M.
Egypt, Cairo
Faculty of Medicine
Darwish, Moshera Hassan
Egypt, Giza
Cairo University
Khalifa, Heba Ahmed
Egypt, Giza
Cairo University
Statistics
Citations: 83
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.3233/NRE-131020
ISSN:
10538135
e-ISSN:
18786448
Research Areas
Mental Health
Noncommunicable Diseases