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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010
PLoS Medicine, Volume 10, No. 11, Article e1001547, Year 2013
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Description
Background:Depressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders as a risk factor for suicide and ischemic heart disease.Methods and Findings:Burden was calculated for major depressive disorder (MDD) and dysthymia. A systematic review of epidemiological data was conducted. The data were pooled using a Bayesian meta-regression. Disability weights from population survey data quantified the severity of health loss from depressive disorders. These weights were used to calculate years lived with disability (YLDs) and disability adjusted life years (DALYs). Separate DALYs were estimated for suicide and ischemic heart disease attributable to depressive disorders.Depressive disorders were the second leading cause of YLDs in 2010. MDD accounted for 8.2% (5.9%-10.8%) of global YLDs and dysthymia for 1.4% (0.9%-2.0%). Depressive disorders were a leading cause of DALYs even though no mortality was attributed to them as the underlying cause. MDD accounted for 2.5% (1.9%-3.2%) of global DALYs and dysthymia for 0.5% (0.3%-0.6%). There was more regional variation in burden for MDD than for dysthymia; with higher estimates in females, and adults of working age. Whilst burden increased by 37.5% between 1990 and 2010, this was due to population growth and ageing. MDD explained 16 million suicide DALYs and almost 4 million ischemic heart disease DALYs. This attributable burden would increase the overall burden of depressive disorders from 3.0% (2.2%-3.8%) to 3.8% (3.0%-4.7%) of global DALYs.Conclusions:GBD 2010 identified depressive disorders as a leading cause of burden. MDD was also a contributor of burden allocated to suicide and ischemic heart disease. These findings emphasize the importance of including depressive disorders as a public-health priority and implementing cost-effective interventions to reduce its burden.Please see later in the article for the Editors' Summary. © 2013 Ferrari et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3818162/bin/pmed.1001547.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3818162/bin/pmed.1001547.s002.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3818162/bin/pmed.1001547.s003.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3818162/bin/pmed.1001547.s004.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3818162/bin/pmed.1001547.s005.docx
Authors & Co-Authors
Ferrari, Alize J.
Australia, Brisbane
The University of Queensland
Charlson, Fiona J.
Australia, Brisbane
The University of Queensland
Pacella, Rosana
Australia, Brisbane
The University of Queensland
Patten, Scott B.
Canada, Calgary
University of Calgary
Freedman, Greg D.
United States, Seattle
Institute for Health Metrics and Evaluation
Murray, Christopher J.L.
United States, Seattle
Institute for Health Metrics and Evaluation
Vos, Theo
Australia, Brisbane
The University of Queensland
United States, Seattle
Institute for Health Metrics and Evaluation
Whiteford, Harvey A.
Australia, Brisbane
The University of Queensland
Statistics
Citations: 2,682
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pmed.1001547
ISSN:
15491676
Research Areas
Disability
Mental Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Systematic review
Participants Gender
Female