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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
dentistry
Immunolocalization of Bone Morphogenetic Protein-2 and -3 and Osteogenic Protein-1 during murine tooth root morphogenesis and in other craniofacial structures
European Journal of Oral Sciences, Volume 107, No. 5, Year 1999
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Description
The distribution of Bone Morphogenetic Protein-2, and -3 (BMP-2 and BMP-3) and Osteogenic Protein-1 (OP-1, also known as BMP-7) during root morphogenesis and in other craniofacial structures was examined in sections of 12- to 18-d-old mouse heads using polyclonal and monoclonal antibodies. BMP-3 and OP-1 were localized in alveolar bone, cementum, and periodontal ligament, whereas BMP-2 was only localized in the alveolar bone of periodontium. All three BMPs were localized in predentine, dentine, odontoblasts, osteoblasts, osteocytes, osteoid, cartilage, chondrocytes and spiral limbus. BMP-2 and OP-1 were also localized in spiral ligament and interdentale cells of the cochlea, whilst BMP-3 was restricted to the spiral ganglion. BMP-3 was also localized in ducts of submandibular and sublingual salivary glands, acini of the lacrimal gland, Purkinje cells in the cerebellum, nerve fibres of the cerebellum and brain, afferent cells of the dorsal root ganglia, inferior alveolar nerve, and peripheral processes of the vestibulocochlear nerve. OP-1 was also localized in hair and whisker follicles, sciera of the eye and in ameloblasts. The demonstration of BMP-3 in the nervous system suggests that this protein may be neurotrophic during development and maintenance of the nervous system. The composite expression of BMPs/OPs during periodontal tissue morphogenesis suggests that optimal therapeutic regeneration may entail the combined use of different BMPs/OPs. © Eur J Oral Sci, 1999.
Authors & Co-Authors
Thomadakis, Georgios
South Africa, Johannesburg
University of the Witwatersrand
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Ramoshebi, Lentsha Nathaniel
South Africa, Johannesburg
University of the Witwatersrand
Crooks, Jean
South Africa, Johannesburg
University of the Witwatersrand
Rueger, David C.
United States, Cambridge
Curis, Inc.
Ripamonti, Ugo
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 106
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1046/j.0909-8836.1999.eos107508.x
ISSN:
09098836
e-ISSN:
16000722
Research Areas
Health System And Policy