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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals
Journal of Infectious Diseases, Volume 208, No. 8, Year 2013
Notification
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Description
Background. The role of active hepatitis C virus (HCV) replication in chronic kidney disease (CKD) risk has not been clarified.Methods. We compared CKD incidence in a large cohort of HIV-infected subjects who were HCV seronegative, HCV viremic (detectable HCV RNA), or HCV aviremic (HCV seropositive, undetectable HCV RNA). Stages 3 and 5 CKD were defined according to standard criteria. Progressive CKD was defined as a sustained 25% glomerular filtration rate (GFR) decrease from baseline to a GFR < 60 mL/min/1.73 m 2. We used Cox models to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).Results. A total of 52 602 HCV seronegative, 9508 HCV viremic, and 913 HCV aviremic subjects were included. Compared with HCV seronegative subjects, HCV viremic subjects were at increased risk for stage 3 CKD (adjusted HR 1.36 [95% CI, 1.26, 1.46]), stage 5 CKD (1.95 [1.64, 2.31]), and progressive CKD (1.31 [1.19, 1.44]), while HCV aviremic subjects were also at increased risk for stage 3 CKD (1.19 [0.98, 1.45]), stage 5 CKD (1.69 [1.07, 2.65]), and progressive CKD (1.31 [1.02, 1.68]).Conclusions. Compared with HIV-infected subjects who were HCV seronegative, both HCV viremic and HCV aviremic individuals were at increased risk for moderate and advanced CKD. © 2013 The Author 2013.
Authors & Co-Authors
Lucas, Gregory M.
United States, Baltimore
Johns Hopkins University
Jing, Yuezhou
United States, Baltimore
Johns Hopkins University
Sulkowski, Mark S.
United States, Baltimore
Johns Hopkins University
Abraham, Alison G.
United States, Baltimore
Johns Hopkins University
Estrella, Michelle M.
United States, Baltimore
Johns Hopkins University
Atta, Mohamed Gehad
United States, Baltimore
Johns Hopkins University
Fine, Derek M.
United States, Baltimore
Johns Hopkins University
Klein, Marina Barbara
Canada, Montreal
Université Mcgill
Silverberg, Michael Jonah
United States, Oakland
Kaiser Permanente
Gill, M. John
Canada, Calgary
University of Calgary
Moore, Richard D.
United States, Baltimore
Johns Hopkins University
Gebo, Kelly A.
United States, Baltimore
Johns Hopkins University
Sterling, Timothy R.
United States, Nashville
Vanderbilt University
Butt, Adeel A.
United States, Pittsburgh
University of Pittsburgh
United Arab Emirates, Abu Dhabi
Sheikh Khalifa Medical City
Kirk, Gregory D.
Unknown Affiliation
Benson, Constance Ann
Unknown Affiliation
Bosch, Ronald J.
Unknown Affiliation
Collier, Ann C.
Unknown Affiliation
Boswell, Stephen L.
Unknown Affiliation
Grasso, Chris
Unknown Affiliation
Mayer, Kenneth H.
Unknown Affiliation
Hogg, Robert S.
Unknown Affiliation
Harrigan, P. Richard
Unknown Affiliation
Montaner, Julio S.G.
Unknown Affiliation
Cescon, Angela M.
Unknown Affiliation
Brooks, John T.
Unknown Affiliation
Buchacz, Kate A.
Unknown Affiliation
Carey, John T.
Unknown Affiliation
Rodriguez, Benigno A.
Unknown Affiliation
Horberg, Michael Alan
Unknown Affiliation
Thorne, Jennifer E.
Unknown Affiliation
Goedert, James Jerome
Unknown Affiliation
Jacobson, Lisa P.
Unknown Affiliation
Rourke, Sean B.
Unknown Affiliation
Burchell, Ann N.
Unknown Affiliation
Rachlis, Anita Rochelle
Unknown Affiliation
Rico, Puerto
Unknown Affiliation
Hunter-Mellado, Robert F.
Unknown Affiliation
Mayor, Ángel M.
Unknown Affiliation
Deeks, Steven G.
Unknown Affiliation
Martin, Jeffrey N.
Unknown Affiliation
Patel, Pragna
Unknown Affiliation
Saag, Michael S.
Unknown Affiliation
Mugavero, Michael J.
Unknown Affiliation
Willig, James H.
Unknown Affiliation
Eron, Joseph J.
Unknown Affiliation
Napravnik, Sonia
Unknown Affiliation
Kitahata, Mari M.
Unknown Affiliation
Crane, Heidi M.
Unknown Affiliation
Justice, Amy C.
Unknown Affiliation
Dubrow, Robert
Unknown Affiliation
Fiellin, David A.
Unknown Affiliation
Haas, David William
Unknown Affiliation
Bebawy, Sally S.
Unknown Affiliation
Turner, Megan M.
Unknown Affiliation
Gange, Stephen J.
Unknown Affiliation
Anastos, Kathryn M.
Unknown Affiliation
McKaig, Rosemary G.
Unknown Affiliation
Freeman, Aimee M.
Unknown Affiliation
Lent, Carol
Unknown Affiliation
van Rompaey, Stephen E.
Unknown Affiliation
Webster, Eric
Unknown Affiliation
Morton, Liz
Unknown Affiliation
Simon, Brenda
Unknown Affiliation
Althoff, Keri N.
Unknown Affiliation
Lau, Bryan M.
Unknown Affiliation
Zhang, Jinbing
Unknown Affiliation
Jing, Jerry
Unknown Affiliation
Golub, Elizabeth Topper
Unknown Affiliation
Modur, Sharada P.
Unknown Affiliation
Hanna, David B.
Unknown Affiliation
Rebeiro, Peter F.
Unknown Affiliation
Wong, Cherise
Unknown Affiliation
Mendes, Adell
Unknown Affiliation
Statistics
Citations: 74
Authors: 74
Affiliations: 7
Identifiers
Doi:
10.1093/infdis/jit373
ISSN:
00221899
Research Areas
Environmental
Infectious Diseases
Noncommunicable Diseases
Study Design
Cohort Study