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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancer
Cell Cycle, Volume 10, No. 15, Year 2011
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Description
The AP-1 transcription factor complex has been implicated in a variety of biological processes including cell differentiation, proliferation, apoptosis and oncogenic transformation. We previously established that activation of the AP-1 family member JunD contributes to deregulated expression of the anti-apoptotic IL-6 gene in prostate cancer cells. We now show that inhibition of JunD in prostate cancer cells results in GADD45α and γ dependent induction of cell death and inhibition of tumor growth that is mediated at least partially via c-Jun N-terminal kinase (JNK) and p38 kinase activation. Apoptosis induction by dominant negative JunD and JNK and p38 kinase activation are impeded upon knock down of GADD45α and γ expression by small interfering RNA, most vividly demonstrating the central role of GADD45α and γ in JunD-mediated escape of prostate cancer cells from programmed cell death. © 2011 Landes Bioscience.
Authors & Co-Authors
Zerbini, Luiz Fernando
South Africa, Cape Town
International Center for Genetic Engineering and Biotechnology Icgeb
Israel
Beth Israel Deaconess Medical Center Genomics and Proteomics Center
De Vasconcellos, Jaíra Ferreira
Israel
Beth Israel Deaconess Medical Center Genomics and Proteomics Center
Czibere, Akos
Israel
Beth Israel Deaconess Medical Center Genomics and Proteomics Center
Wang, Yihong
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Paccez, Juliano D.
South Africa, Cape Town
International Center for Genetic Engineering and Biotechnology Icgeb
Gu, Xuesong
Israel
Beth Israel Deaconess Medical Center Genomics and Proteomics Center
Zhou, Jin Rong
United States, Boston
Harvard Medical School
Libermann, Towia Aron
Israel
Beth Israel Deaconess Medical Center Genomics and Proteomics Center
Statistics
Citations: 27
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.4161/cc.10.15.16057
ISSN:
15384101
e-ISSN:
15514005
Research Areas
Cancer
Genetics And Genomics