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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of Changes in Body Mass Index on the Risk of Cardiovascular Disease and Diabetes Mellitus in HIV-Positive Individuals: Results from the D:A:D Study
Journal of Acquired Immune Deficiency Syndromes, Volume 86, No. 5, Year 2021
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Description
Background:Weight gain is common among people with HIV once antiretroviral treatment is commenced. We assess the effect of changes in body mass index (BMI), from different baseline BMI levels, on the risk of cardiovascular disease (CVD) and diabetes mellitus (DM).Methods:D:A:D participants receiving antiretroviral treatment were followed from their first BMI measurement to the first of either CVD or DM event, or earliest of January 2, 2016 or 6 months after last follow-up. Participants were stratified according to their baseline BMI, and changes from baseline BMI were calculated for each participant. Poisson regression models were used to assess the effects of changes on BMI on CVD or DM events.Results:There were 2104 CVD and 1583 DM events over 365,287 and 354,898 person-years [rate: CVD 5.8/1000 (95% confidence interval: 5.5 to 6.0); DM 4.5/1000 (95% confidence interval: 4.2 to 4.7)]. Participants were largely men (74%), baseline mean age of 40 years, and median BMI of 23.0 (IQR: 21.0-25.3). A risk of CVD by change in BMI from baseline, stratified by baseline BMI strata showed little evidence of an increased risk of CVD with an increased BMI in any baseline BMI strata. An increase in BMI was associated with an increased risk of DM across all baseline BMI strata.Conclusions:Although increases in BMI across all levels of baseline BMI were not associated with an increased risk of CVD, such changes were consistently associated with an increased risk of DM. There was also some evidence of an increased risk of CVD with a decrease in BMI. © 2020 Wolters Kluwer Health, Inc.
Authors & Co-Authors
Petoumenos, Kathy
Australia, Sydney
Unsw Sydney
Kuwanda, Locadiah
Australia, Sydney
Unsw Sydney
Ryom, Lene
Denmark, Copenhagen
Rigshospitalet
Mocroft, Amanda J.
United Kingdom, London
University College London
Reiss, Peter
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
Stichting Hiv Monitoring
de Wit, Stéphane
Belgium, Brussels
Université Libre de Bruxelles
Pradier, Christian
France, Nice
Centre Hospitalier Universitaire de Nice
Bonnet, Fabrice
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Phillips, Andrew N.
United Kingdom, London
University College London
Hatleberg, Camilla Ingrid
Denmark, Copenhagen
Rigshospitalet
d'Arminio-Monforte, Antonella
Italy, Milan
Ospedale San Paolo
Weber, Rainer
Switzerland, Zurich
Universität Zürich
Sabin, Caroline A.
United Kingdom, London
University College London
Lundgren, Jens Dilling
Denmark, Copenhagen
Rigshospitalet
Law, Matthew G.
Australia, Sydney
Unsw Sydney
Statistics
Citations: 15
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1097/QAI.0000000000002603
ISSN:
15254135
Research Areas
Infectious Diseases
Noncommunicable Diseases
Study Design
Cohort Study
Participants Gender
Male