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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Venomics and antivenomics profiles of North African Cerastes cerastes and C. vipera populations reveals a potentially important therapeutic weakness
Journal of Proteomics, Volume 75, No. 8, Year 2012
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Description
We report the proteomic analysis of the venom of the medically relevant snake, Cerastes cerastes, from Morocco, and the immunoreactivity profile of an experimental monospecific (CcMo_AV against Moroccan C. cerastes venom) and a commercial (Gamma-VIP against Tunisian C. cerastes and M. lebetina venoms) F(ab') 2 antivenoms towards geographic variants of C. cerastes and C. vipera venoms. The venom of C. cerastes is a low-complexity proteome composed of 25-30 toxins belonging to 6 protein families, mainly targetting the hemostatic system. This toxin arsenal explains the clinical picture observed in C. cerastes envenomings. Despite geographic compositional variation, the monospecific CcMo_AV and the Gamma-VIP divalent antivenom produced at Institut Pasteur de Tunis, showed similar immunocapturing capability towards Moroccan, Tunisian, and Egyptian C. cerastes venom proteins. Proteins partially escaping immunorecognition were all identified as PLA 2 molecules. Antivenomic analysis showed low degree of cross-reactivity of Moroccan CcMo_AV and Tunisian Gamma-VIP antivenoms towards C. vipera venom toxins. This study indicates that a more complete therapeutic cover could be achieved by including C. vipera venom in the formulation of venom immunization mixtures, thereby generating a pan-Cerastes antivenom. © 2012 Elsevier B.V.
Authors & Co-Authors
Fahmi, Laila
Morocco, Casablanca
Institut Pasteur du Maroc
Makran, Bouchra
Morocco, Casablanca
Institut Pasteur du Maroc
Pla, Davinia
Spain, Valencia
Csic - Instituto de Biomedicina de Valencia Ibv
Sanz, Libia
Spain, Valencia
Csic - Instituto de Biomedicina de Valencia Ibv
Oukkache, Naoual
Morocco, Casablanca
Institut Pasteur du Maroc
Lkhider, Mustapha
Morocco, El Jadida
Faculté Des Sciences D'el Jadida
Harrison, Robert A.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Ghalim, Noreddine
Morocco, Casablanca
Institut Pasteur du Maroc
Calvete, Juan J.
Spain, Valencia
Csic - Instituto de Biomedicina de Valencia Ibv
Spain, Valencia
Universitat Politècnica de València
Statistics
Citations: 50
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.jprot.2012.02.021
ISSN:
18743919
e-ISSN:
18767737
Research Areas
Maternal And Child Health
Study Locations
Morocco