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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Functional antibodies against VAR2CSA in nonpregnant populations from colombia exposed to Plasmodium falciparum and Plasmodium vivax
Infection and Immunity, Volume 82, No. 6, Year 2014
Notification
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Description
In pregnancy, parity-dependent immunity is observed in response to placental infection with Plasmodium falciparum. Antibodies recognize the surface antigen, VAR2CSA, expressed on infected red blood cells and inhibit cytoadherence to the placental tissue. In most settings of malaria endemicity, antibodies against VAR2CSA are predominantly observed in multigravid women and infrequently in men, children, and nulligravid women. However, in Colombia, we detected antibodies against multiple constructs of VAR2CSA among men and children with acute P. falciparum and Plasmodium vivax infection. The majority of men and children (>60%) had high levels of IgGs against three recombinant domains of VAR2CSA: DBL5ε, DBL3X, and ID1-ID2. Surprisingly, these antibodies were observed only in pregnant women, men, and children exposed either to P. falciparum or to P. vivax. Moreover, the anti-VAR2CSA antibodies are of high avidity and efficiently inhibit adherence of infected red blood cells to chondroitin sulfate A in vitro, suggesting that they are specific and functional. These unexpected results suggest that there may be genotypic or phenotypic differences in the parasites of this region or in the host response to either P. falciparum or P. vivax infection outside pregnancy. These findings may hold significant clinical relevance to the pathophysiology and outcome of malaria infections in this region. © 2014, American Society for Microbiology.
Authors & Co-Authors
Gnidéhou, Sédami
Canada, Edmonton
University of Alberta
Doritchamou, Justin
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Arango, Eliana M.
Colombia, Medellin
Universidad de Antioquia
Cabrera, Ana
Canada, Toronto
Sandra Rotman Centre for Global Health
Canada, Toronto
University Health Network University of Toronto
Kain, Kevin C.
Canada, Toronto
Sandra Rotman Centre for Global Health
Canada, Toronto
University Health Network University of Toronto
Canada, Toronto
University of Toronto
Tuikue-Ndam, Nicaise
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Maestre, A. Elena
Colombia, Medellin
Universidad de Antioquia
Yanowa, Stephanie K.
Canada, Calgary
Provincial Laboratory for Public Health, Alberta
Statistics
Citations: 27
Authors: 8
Affiliations: 8
Identifiers
Doi:
10.1128/IAI.01594-14
ISSN:
00199567
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Male
Female