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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnosis of malaria by detection of Plasmodium falciparum HRP-2 antigen with a rapid dipstick antigen-capture assay
The Lancet, Volume 343, No. 8897, Year 1994
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Description
Two field studies in Kenya and an experimental challenge study in the USA were done to assess the accuracy of a dipstick antigen-capture assay based on qualitative detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP-2) in peripheral blood for diagnosis of P falciparum infection. In these studies, the assay was 96·5-100% sensitive for detection of greater than 60 P falciparum asexual parasites/ μL blood, 70-81% sensitive for 11-60 parasites/μL blood, and 11-67% sensitive for 10 parasites or less/μL blood. Specificity was 95% (95% Cl 85-105%; n = 20) among naive American volunteers, 98% (96-101%; n=112) among volunteers exposed to the bite of P falciparium-infected mosquitoes, and 88% (84-92%; n=285) among Kenyans living in an area with holoendemic malaria. Our results also indicated that PfHRP-2 antigen was not detectable in blood 6 days after initiation of curative chemotherapy, and suggest that such circulating antigens rarely lead to false-positive tests. The dipstick assay's sensitivity, specificity, simplicity, and speed may make it an important tool in the battle against malaria. © 1994.
Authors & Co-Authors
Beadle, Christine
United States, Bethesda
Naval Medical Research Institute, Bethesda
Long, Gary W.
United States, Bethesda
Naval Medical Research Institute, Bethesda
McElroy, Peter D.
United States, Bethesda
Naval Medical Research Institute, Bethesda
Hoffman, Stephen L.
United States, Bethesda
Naval Medical Research Institute, Bethesda
Long, G. W.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Weiss, Walter R.
Kenya, Nairobi
Us Army Medical Research Unit-kenya
Maret, S. Melissa
United States, Baltimore
Becton Dickinson Company
Oloo, Aggrey James
Kenya, Nairobi
Kenya Medical Research Institute
Statistics
Citations: 323
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/S0140-6736(94)91520-2
ISSN:
01406736
Research Areas
Cancer
Infectious Diseases
Study Approach
Qualitative
Study Locations
Kenya