Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans
Cell Host and Microbe, Volume 5, No. 5, Year 2009
Notification
URL copied to clipboard!
Description
Candida albicans is an opportunistic fungal pathogen causing life-threatening mucosal and systemic infections in immunocompromised humans. Using a murine model of mucosal Candida infection, we investigated the role of the proinflammatory cytokine IL-1β in host defense to Candida albicans. We find that the synthesis, processing, and release of IL-1β in response to Candida are tightly controlled and first require transcriptional induction, followed by a second signal leading to caspase-1-mediated cleavage of the pro-IL-1β cytokine. The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1β gene transcription, whereas the NLRP3-containing proinflammatory multiprotein complex, the NLRP3 inflammasome, controls caspase-1-mediated cleavage of pro-IL-1β. Furthermore, we show that TLR2, Dectin-1, and NLRP3 are essential for defense against dissemination of mucosal infection and mortality in vivo. Therefore, in addition to sensing bacterial and viral pathogens, the NLRP3 inflammasome senses fungal pathogens and is critical in host defense against Candida. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Hise, Amy G.
United States, Cleveland
Case School of Medicine
Tomalka, Jeffrey
United States, Cleveland
Case School of Medicine
Ganesan, Sandhya
United States, Worcester
University of Massachusetts Chan Medical School
Patel, Krupen
United States, Cleveland
Case School of Medicine
Hall, Brian A.
United States, Cleveland
Case School of Medicine
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
Fitzgerald, Katherine A.
United States, Worcester
University of Massachusetts Chan Medical School
Statistics
Citations: 546
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.chom.2009.05.002
ISSN:
19313128
Research Areas
Genetics And Genomics