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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Carriage of Neisseria lactamica in 1- to 29-year-old people in Burkina Faso: Epidemiology and molecular characterization
Journal of Clinical Microbiology, Volume 50, No. 12, Year 2012
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Description
Neisseria lactamica is a true commensal bacterium occupying the same ecological niche as the pathogenic Neisseria meningitidis, which is responsible for outbreaks and large epidemics, especially in sub-Saharan Africa. To better understand the epidemiology of N. lactamica in Africa and its relationship to N. meningitidis, we studied N. lactamica carriage in 1- to 29-year-old people living in three districts of Burkina Faso from 2009 to 2011. N. lactamica was detected in 18.2% of 45,847 oropharyngeal samples. Carriage prevalence was highest among the 2-year-olds (40.1%) and decreased with age. Overall prevalence was higher for males (19.1%) than females (17.5%) (odds ratio [OR], 1.11; 95% confidence interval [CI], 1.04 to 1.18), while among the 18- to 29-year-olds, carriage prevalence was significantly higher in women (9.1%) than in men (3.9%) (OR, 2.49; 95% CI, 1.94 to 3.19). Carriage prevalence of N. lactamica was remarkably homogeneous in the three districts of Burkina Faso and stable over time, in comparison with carriage of N. meningitidis (P. A. Kristiansen et al., Clin. Vaccine Immunol. 18:435-443, 2011). There was no significant seasonal variation of N. lactamica carriage and no significant change in carriage prevalence after introduction of the serogroup A meningococcal conjugate vaccine, MenAfriVac. Multilocus sequence typing was performed on a selection of 142 isolates. The genetic diversity was high, as we identified 62 different genotypes, of which 56 were new. The epidemiology of N. lactamica carriage and the molecular characteristics of carried isolates were similar to those reported from industrialized countries, in contrast to the particularities of N. meningitidis carriage and disease epidemiology in Burkina Faso. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Kristiansen, Paul Arne
Norway, Oslo
Folkehelseinstituttet
Diomandé, Fabien V.K.
Burkina Faso, Ouagadougou
World Health Organization Ouagadougou
United States, Atlanta
Centers for Disease Control and Prevention
Ouédraogo-Traoré, Rasmata
Burkina Faso, Ouagadougou
Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle
Sanou, Idrissa
Burkina Faso, Bobo-dioulasso
Centre Hospitalier Universitaire Souro Sanou
Burkina Faso, Ouagadougou
Ministere de la Sante Ouagadougou
Sangaré, Lassana
Burkina Faso, Bobo-dioulasso
Centre Hospitalier Universitaire Souro Sanou
Ouédraogo, Abdoul Salam
Burkina Faso, Ouagadougou
Ministere de la Sante Ouagadougou
Ba, Absatou Ky
Burkina Faso, Ouagadougou
World Health Organization Ouagadougou
Kandolo, Denis
Burkina Faso, Ouagadougou
World Health Organization Ouagadougou
France, Ferney-voltaire
Meningitis Vaccine Project
Thomas, Jennifer Dolan
United States, Atlanta
Centers for Disease Control and Prevention
Clark, Thomas A.
United States, Atlanta
Centers for Disease Control and Prevention
Préziosi, Marie Pierre
Switzerland, Geneva
Organisation Mondiale de la Santé
Norway, Oslo
Medisinske Fakultet
LaForce, F. Marc
Switzerland, Geneva
Organisation Mondiale de la Santé
Caugant, Dominique A.
Norway, Oslo
Folkehelseinstituttet
Statistics
Citations: 31
Authors: 13
Affiliations: 9
Identifiers
Doi:
10.1128/JCM.01717-12
ISSN:
00951137
e-ISSN:
1098660X
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Burkina Faso
Participants Gender
Male
Female