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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Antiretroviral therapy and sexual behavior in Uganda: A cohort study
AIDS, Volume 25, No. 5, Year 2011
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Description
Objective: To assess evidence for sexual behavior change in response to antiretroviral therapy (ART) among members of a Ugandan clinical cohort. Secondarily, to examine factors associated with both sexual behavior and ART independently, that may help to assess the impact that ART is likely to have on the HIV epidemic. Design: Retrospective analysis of data from an open cohort. Methods: ART roll-out began in the cohort in 2004. Using 3-monthly data from 2002 to 2009, we conducted regression and descriptive analyses to examine associations between timing of ART initiation and sexual behavior among HIV-infected, and timing of ART availability and sexual behavior among HIV-uninfected. We also examined partner turnover rates, and the proportion of HIV-infected on ART - two important factors for modeling the potential impact of ART on the HIV epidemic. Results: Risky sexual behavior among HIV-infected people rose on several indicators after ART initiation, but not to levels higher than two or more years before initiation. Some evidence suggests that the availability of ART may impact risky behavior among HIV-uninfected people, although this was inconsistent across different reported behavior variables. Conclusion: The HIV-uninfected is larger than the HIV-infected population. If risky behavior among this population increases due to the feeling of safety that ART provides, this will affect the impact of ART on the HIV epidemic. Policy makers are urged to intensify messages associating sexual behavior and HIV and to target both HIV-infected and uninfected people. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Shafer, Leigh Anne
Unknown Affiliation
Nsubuga, Rebecca Namugabwe
Unknown Affiliation
White, Richard G.
Unknown Affiliation
Mayanja, Billy Nsubuga
Unknown Affiliation
Chapman, Ruth
Unknown Affiliation
O'Brien, Katie M.
Unknown Affiliation
van der Paal, Lieve
Unknown Affiliation
Grosskurth, Heiner
Unknown Affiliation
Maher, Dermot P.
Unknown Affiliation
Statistics
Citations: 33
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1097/QAD.0b013e328341fb18
e-ISSN:
14735571
Research Areas
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Uganda