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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Early antiretroviral therapy improves neurodevelopmental outcomes in infants
AIDS, Volume 26, No. 13, Year 2012
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Description
Objectives: To evaluate the effect of early versus deferred antiretroviral therapy (ART) on the neurodevelopment of infants from Cape Town participating in the Children with HIV Early Antiretroviral Therapy (CHER) trial. Design: HIV-infected infants were randomized to early (<3 months) or deferred ART. HIV-uninfected infants (HIV-exposed and HIV-unexposed) provide background data. Methods: Neurological examination and Griffiths Mental Development Scales (GMDS) were administered between 10-16 months of age by testers blind to HIV status and randomized allocation. Mean quotients were compared using paired Student's t-tests. Results: Sixty-four infants on early ART and 26 on deferred ART (of potential 77 and 38 respectively on CHER trial) were assessed at median age 11 months (range 10-16). On the GMDS, all scores were lower in the deferred arm and the General Griffiths and Locomotor Scores were significantly lower: mean (SD)=100.1 (13.8) vs. 106.3 (10.6) P=0.02; and 88.9 (16.3) vs. 97.7 (12.5), P<0.01, respectively. Children with HIV who received early ART performed as well as children without HIV except on the Locomotor subscale. Both infected and uninfected mean GMDS scores were within the average range. Conclusion: Infants initiated on early ART have significantly better Locomotor and general scores on the GMDS at median age 11 months compared to infants on deferred ART, despite careful monitoring and ready access to ART in the latter. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Laughton, Barbara
South Africa, Tygerberg
Tygerberg Hospital
Cornell, M.
South Africa, Cape Town
University of Cape Town
Grovè, Debbie V.
South Africa, Stellenbosch
Stellenbosch University
Kidd, Martin
South Africa, Stellenbosch
Stellenbosch University
Springer, Priscilla Estelle
South Africa, Tygerberg
Tygerberg Hospital
Dobbels, Els Francßoise Marie Théerèese
South Africa, Tygerberg
Tygerberg Hospital
van Rensburg, Anita Janse
South Africa, Tygerberg
Tygerberg Hospital
Violari, Avy
South Africa, Johannesburg
University of the Witwatersrand
Babiker, Abdel G.A.G.
United Kingdom, London
Medical Research Council
Madhi, Shabir A.
South Africa, Johannesburg
University of the Witwatersrand
Jean-Philippe, Patrick
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Gibb, Diana M.
United Kingdom, London
Medical Research Council
Cotton, Mark Fredric
South Africa, Tygerberg
Tygerberg Hospital
Statistics
Citations: 168
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1097/QAD.0b013e328355d0ce
e-ISSN:
14735571
Research Areas
Disability
Health System And Policy
Infectious Diseases
Maternal And Child Health