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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pneumococcal capsular switching: A historical perspective
Journal of Infectious Diseases, Volume 207, No. 3, Year 2013
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Description
Background. Changes in serotype prevalence among pneumococcal populations result from both serotype replacement and serotype (capsular) switching. Temporal changes in serotype distributions are well documented, but the contribution of capsular switching to such changes is unknown. Furthermore, it is unclear to what extent vaccine-induced selective pressures drive capsular switching.Methods. Serotype and multilocus sequence typing data for 426 pneumococci dated from 1937 through 2007 were analyzed. Whole-genome sequence data for a subset of isolates were used to investigate capsular switching events.Results. We identified 36 independent capsular switch events, 18 of which were explored in detail with whole-genome sequence data. Recombination fragment lengths were estimated for 11 events and ranged from approximately 19.0 kb to ≥58.2 kb. Two events took place no later than 1960, and the imported DNA included the capsular locus and the nearby penicillin-binding protein genes pbp2x and pbp1a.Conclusions. Capsular switching has been a regular occurrence among pneumococcal populations throughout the past 7 decades. Recombination of large DNA fragments (>30 kb), sometimes including the capsular locus and penicillin-binding protein genes, predated both vaccine introduction and widespread antibiotic use. This type of recombination has likely been an intrinsic feature throughout the history of pneumococcal evolution. © 2012 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3537446/bin/supp_207_3_439__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3537446/bin/supp_jis703_jis703supp.docx
Authors & Co-Authors
Wyres, Kelly L.
United Kingdom, Oxford
University of Oxford
Lambertsen, Lotte Munch
Denmark, Copenhagen
Statens Serum Institut
Croucher, Nicholas J.
United Kingdom, Hinxton
Wellcome Sanger Institute
McGee, Lesley
United States, Atlanta
Centers for Disease Control and Prevention
von Gottberg, Anne M.
South Africa, Johannesburg
National Institute for Communicable Diseases
Liñares, J. P.
Spain, Barcelona
Hospital Universitari de Bellvitge
Jacobs, Michael R.
United States, Cleveland
Case Western Reserve University
Kristinsson, Karl Gustaf
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Beall, Bernard W.
United States, Atlanta
Centers for Disease Control and Prevention
Klugman, K. P.
United States, Atlanta
Emory University
South Africa, Johannesburg
National Institute for Communicable Diseases
Parkhill, Julian
United Kingdom, Hinxton
Wellcome Sanger Institute
Hakenbeck, Regine
Germany, Kaiserslautern
Technische Universität Kaiserslautern
Bentley, Stephen D.
United Kingdom, Hinxton
Wellcome Sanger Institute
Brueggemann, Angela B.
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 14
Authors: 14
Affiliations: 10
Identifiers
Doi:
10.1093/infdis/jis703
ISSN:
00221899
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study