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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study
Neuroepidemiology, Volume 55, No. 3, Year 2021
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Description
Background: Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association. Aims: We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations. Methods: INTERSTROKE is a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries. We included individuals with available serum creatinine values and calculated estimated glomerular filtration rate (eGFR). Renal impairment was defined as eGFR <60 mL/min/1.73 m2. Multivariable conditional logistic regression was used to determine the association of renal function with stroke. Results: Of 21,127 participants, 41.0% were female, the mean age was 62.3 ± 13.4 years, and the mean eGFR was 79.9 ± 23.5 mL/min/1.73 m2. The prevalence of renal impairment was higher in cases (22.9% vs. 17.7%, p < 0.001) and differed by region (p < 0.001). After adjustment, lower eGFR was associated with increased odds of stroke. Renal impairment was associated with increased odds of all stroke (OR 1.35; 95% CI: 1.24-1.47), with higher odds for intracerebral hemorrhage (OR 1.60; 95% CI: 1.35-1.89) than ischemic stroke (OR 1.29; 95% CI: 1.17-1.42) (pinteraction 0.12). The largest magnitudes of association were seen in younger participants and those living in Africa, South Asia, or South America (pinteraction < 0.001 for all stroke). Renal impairment was also associated with poorer clinical outcome (RRR 2.97; 95% CI: 2.50-3.54 for death within 1 month). Conclusion: Renal impairment is an important risk factor for stroke, particularly in younger patients, and is associated with more severe stroke and worse outcomes. © 2021
Authors & Co-Authors
Smyth, Andrew
Canada, Hamilton
Population Health Research Institute, Ontario
United States, Chicago
Rush University Medical Center
Ireland, Galway
University of Galway
Judge, Conor S.
Canada, Hamilton
Population Health Research Institute, Ontario
United States, Chicago
Rush University Medical Center
Ireland, Galway
University of Galway
Wang, Xingu
Ireland, Galway
University Hospital Galway
Paré, Guillaume
Canada, Hamilton
Population Health Research Institute, Ontario
Rangarajan, Sumathy
Canada, Hamilton
Population Health Research Institute, Ontario
Canavan, M. D.
United States, Chicago
Rush University Medical Center
Chin, Siu Lim
Canada, Hamilton
Population Health Research Institute, Ontario
Al-Hussain, Fawaz Abdulaziz
China, Beijing
Beijing Hypertension League Institute
Yusufali, Afzal Hussein
Saudi Arabia, Riyadh
King Saud University
ElSayed, Ahmed Sayed
United Arab Emirates, Dubai
Dubai Medical College
Damasceno, A. Antonio Moura
Sudan, Khartoum
Alzaiem Alazhari University
Avezum, Álvaro Jr
Mozambique, Maputo
Universidade Eduardo Mondlane
Członkowska, Anna
Brazil, Sao Paulo
Hospital Alemao Oswaldo Cruz
Rosengren, Annika H.
Poland, Warsaw
Institute of Psychiatry and Neurology, Warszawa
Dans, Antonio L.L.
Sweden, Gothenburg
Sahlgrenska Akademin
Oǧuz, Aytekin
Philippines, Manila
University of the Philippines Manila
Mondo, Charles Kiiza
Turkey, Istanbul
Istanbul Medeniyet University
Weimar, Christian
Uganda, Kampala
Mulago Hospital
Ryglewicz, Danuta Krystyna
Germany, Essen
Universitätsklinikum Essen
Xavier, Denis
Poland, Warsaw
Military Institute of Aviation Medicine
Málaga, Germán M.
Chile, Temuco
Universidad de la Frontera
Hankey, Graeme J.
Peru, Lima
Universidad Peruana Cayetano Heredia
Iversen, Helle Klingenberg
Australia, Perth
The University of Western Australia
Zhang, Hongye
Ireland, Galway
University Hospital Galway
Yusoff, Khalid
Denmark, Copenhagen
Rigshospitalet
Posogova, Nana
Malaysia, Shah Alam
Universiti Teknologi Mara
Lopez-Jamarillo, Patricio
Russian Federation, Moscow
National Medical Research Center of Cardiology of the Ministry of Healthcare of the Russian Federation
Langhorne, Peter
Colombia, Bucaramanga
Universidad de Santander
Díaz, Rafaël J.
United Kingdom, Glasgow
Glasgow Royal Infirmary
Argentina, Rosario
Estudios Clínicos Latinoamérica, Argentina
Oveisgharan, Shahram
Canada, Hamilton
Population Health Research Institute, Ontario
Yusuf, Salim N.
Canada, Hamilton
Population Health Research Institute, Ontario
O'Donnell, Martin J.
Canada, Hamilton
Population Health Research Institute, Ontario
United States, Chicago
Rush University Medical Center
Statistics
Citations: 7
Authors: 32
Affiliations: 27
Identifiers
Doi:
10.1159/000515239
ISSN:
02515350
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study
Participants Gender
Female