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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evidence of person-to-person transmission of hepatitis e virus during a large outbreak in northern Uganda
Clinical Infectious Diseases, Volume 50, No. 7, Year 2010
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Description
Background: Outbreaks of infection with hepatitis E virus (HEV) are frequently attributed to contaminated drinking water, even if direct evidence for this is lacking. Methods: We conducted several epidemiologic investigations during a large HEV infection outbreak in Uganda. Results. Of 10,535 residents, 3218 had HEV infection; of these, 2531 lived in households with >1 case. HEV was not detected in drinking water or zoonotic sources. Twenty-five percent of cases occurred ≥8 weeks after onset of hepatitis in an index case in the household. Households with ≥2 cases were more likely to have a member(s) who attended a funeral, had close contact with a jaundiced person, or washed hands in a common basin with others (P < .05 for all). Conclusions :A high attack rate in households, lack of a common source of infection, and poor hygienic practices in households with ≥2 cases suggest person-to-person transmission of HEV during this outbreak. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Teshale, Eyasu Habtu
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
United States, Atlanta
Centers for Disease Control and Prevention
Grytdal, Scott P.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Howard, Christopher
United States, Atlanta
National Center for Environmental Health
Barry, Vaughn
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Kamili, Saleem
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Drobeniuc, Jan
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Hill, Vincent R.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Okware, Samuel I.
Uganda, Kampala
Uganda National Health Research Organizations
Hu, Dale J.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Holmberg, Scott D.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Statistics
Citations: 161
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1086/651077
ISSN:
10584838
Research Areas
Environmental
Infectious Diseases
Study Locations
Uganda