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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The influence of clinical risk factors on pre-operative B-type natriuretic peptide risk stratification of vascular surgical patients
Anaesthesia, Volume 67, No. 1, Year 2012
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Description
Summary The role of the revised cardiac risk index in risk stratification has recently been challenged by studies reporting on the superior predictive ability of pre-operative B-type natriuretic peptides. We found that in 850 vascular surgical patients initially risk stratified using B-type natriuretic peptides, reclassification with the number of revised cardiac risk index risk factors worsened risk stratification (p < 0.05 for > 0, > 2, > 3 and > 4 risk factors, and p = 0.23 for > 1 risk factor). When evaluated with pre-operative B-type natriuretic peptides, none of the revised cardiac risk index risk factors were independent predictors of major adverse cardiac events in vascular patients. The only independent predictor was B-type natriuretic peptide stratification (OR 5.1, 95% CI 1.8-15 for the intermediate class, and OR 25, 95% CI 8.7-70 for the high-risk class). The clinical risk factors in the revised cardiac risk index cannot improve a risk stratification model based on B-type natriuretic peptides. Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland.
Authors & Co-Authors
Biccard, Bruce Mclure
South Africa, Durban
University of Kwazulu-natal
Lurati Buse, Giovanna A.L.
Switzerland, Basel
Universitätsspital Basel
Burkhart, Christoph Simon
Switzerland, Basel
Universitätsspital Basel
Cuthbertson, Brian H.
Canada, Toronto
University of Toronto
Filipovic, Miodrag
Switzerland, St Gallen
Kantonsspital St.gallen
Gibson, Simon C.
United Kingdom, Glasgow
New Stobhill Hospital
Mahla, Elisabeth L.
Austria, Graz
Medizinische Universität Graz
Leibowitz, David W.
Israel, Jerusalem
Hebrew University of Jerusalem
Rodseth, Reitze Nils
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 45
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1111/j.1365-2044.2011.06958.x
ISSN:
00032409
e-ISSN:
13652044
Research Areas
Health System And Policy
Noncommunicable Diseases