Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Chlamydia pneumoniae is genetically diverse in animals and appears to have crossed the host barrier to humans on (at least) two occasions
PLoS Pathogens, Volume 6, No. 5, Year 2010
Notification
URL copied to clipboard!
Description
Chlamydia pneumoniae is a common human and animal pathogen associated with a wide range of diseases. Since the first isolation of C. pneumoniae TWAR in 1965, all human isolates have been essentially clonal, providing little evolutionary insight. To address this gap, we investigated the genetic diversity of 30 isolates from diverse geographical locations, from both human and animal origin (amphibian, reptilian, equine and marsupial). Based on the level of variation that we observed at 23 discreet gene loci, it was clearly evident that the animal isolates were more diverse than the isolates of human origin. Furthermore, we show that C. pneumoniae isolates could be grouped into five major genotypes, A-E, with A, B, D and E genotypes linked by geographical location, whereas genotype C was found across multiple continents. Our evidence strongly supports two separate animal-to-human cross species transfer events in the evolutionary history of this pathogen. The C. pneumoniae human genotype identified in the USA, Canada, Taiwan, Iran, Japan, Korea and Australia (non-Indigenous) most likely originated from a single amphibian or reptilian lineage, which appears to have been previously geographically widespread. We identified a separate human lineage present in two Australian Indigenous isolates (independent geographical locations). This lineage is distinct and is present in Australian amphibians as well as a range of Australian marsupials. © 2010 Mitchell et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s001.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s002.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s003.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s004.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s005.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s006.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s007.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s008.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s009.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s010.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s011.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s012.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s013.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s014.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s015.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s016.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s017.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s018.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s019.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s020.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s021.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s022.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s023.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s024.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s025.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s026.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2873915/bin/ppat.1000903.s027.doc
Authors & Co-Authors
Myers, Garry S.A.
United States, Baltimore
University of Maryland, Baltimore Umb
Brunham, Robert C.
Canada, Vancouver
Bc Centre for Disease Control
Timms, Peter Mc Lean
Australia, Brisbane
Queensland University of Technology
Statistics
Citations: 37
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1371/journal.ppat.1000903
ISSN:
15537374
Research Areas
Genetics And Genomics