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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The effect of peginterferon alpha-2a vs. peginterferon alpha-2b in treatment of naive chronic HCV genotype-4 patients: A single centre egyptian study
Hepatitis Monthly, Volume 13, No. 5, Year 2013
Notification
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Description
Background: Egypt has one of the highest (16-8%) prevalence rates of HCV infection in the world. Approximately 90% of Egyptian HCV isolates belong to a single subtype (4a), which responds less successfully to interferon therapy than other subtypes. Studies comparing the efficacy and safety of PEGIFN alfa-2a and PEGIFN alfa-2b in treatment-naive HCV-infected patients have shown conflicting results. Objectives: assessing the effects of Peginterferon alpha-2a versus Peginterferon alpha-2b on the sustained virological response in naive chronic HCV genotype-4 Egyptian patients. Patients and Methods: this retrospective study cohort consists of 3718 chronic HCV patients admitted to a large, Egyptian medical center. 1985 patients had been treated with PEG-IFN alfa-2a plus RBV and 1733 patients with PEG-IFN alfa-2b plus RBV between years 2007-2011. Efficacy outcomes were sustained virologic response (SVR) and treatment discontinuation rates due to serious adverse effects. Results: The ETR & SVR in patients treated with PEGIFN alfa-2a was 64.1% and 59.6% as compared to treatment with PEGIFN alfa-2b where these parameters were 58.2% and 53.9% respectively (P< 0.05). Treatment discontinuation rates, were similar in the two types of PEGIFN [0.66 (0.37-1.16); P = 0.15]. Significant dose reduction was evident with peginterferon alfa-2b (35.3%) than peginterferon alpha-2a (27.3 %) (P< 0.01). Patients with lower base line AFP and ALT were most likely to achieve SVR using INF alpha 2-a. Conclusions: Peginterferon alpha-2a has a higher efficacy regarding ETR and SVR as compared to Peginterferon alfa-2b in treatment of naive chronic HCV genotype-4 patients. © 2013, Kowsar Corp.
Authors & Co-Authors
El-Raziky, Maissa S.
Egypt, Cairo
Faculty of Medicine
Fathalah, Waleed Fouad
Egypt, Cairo
Faculty of Medicine
Elakel, Wafaa Ahmed
Egypt, Cairo
Faculty of Medicine
Salama, Ahmed
Egypt, Cairo
Faculty of Medicine
Esmat, Gamal
Egypt, Cairo
Faculty of Medicine
Mabrouk, Mahasen Abd El Rahman
Egypt, Cairo
Faculty of Medicine
Salama, Rabab Maamoun
Egypt, Cairo
Faculty of Medicine
Khatab, Hany Mahmoud
Egypt, Giza
Cairo University
Statistics
Citations: 47
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.5812/hepatmon.10069
ISSN:
1735143X
e-ISSN:
17353408
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Egypt