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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Genomic investigations of unexplained acute hepatitis in children
Nature, Volume 617, No. 7961, Year 2023
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Description
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children. © 2023, The Author(s).
Authors & Co-Authors
Morfopoulou, Sofia
United Kingdom, London
University College London
United Kingdom, London
Imperial College London
Buddle, Sarah
United Kingdom, London
University College London
Torres Montaguth, Oscar Enrique
United Kingdom, London
University College London
Atkinson, Laura
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Guerra-Assunção, José Afonso
United Kingdom, London
University College London
Moradi Marjaneh, Mahdi
United Kingdom, London
Imperial College London
Zennezini Chiozzi, Riccardo
United Kingdom, London
University College London
Storey, Nathaniel
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Campos, Luis
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Hutchinson, John Ciaran
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Counsell, John R.
United Kingdom, London
University College London
Pollara, Gabriel
United Kingdom, London
University College London
Roy, Sunando
United Kingdom, London
University College London
Venturini, Cristina
United Kingdom, London
University College London
Antinao Diaz, Juan F.
United Kingdom, London
University College London
Siam, Ala'a
United Kingdom, London
University College London
Tappouni, Luke J.
United Kingdom, London
University College London
Asgarian, Zeinab
United Kingdom, London
University College London
Ng, Joanne
United Kingdom, London
University College London
Hanlon, Killian S.
United Kingdom, London
University College London
Lennon, Alexander
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
McArdle, Andrew J.
United Kingdom, London
Imperial College London
Czap, Agata
United Kingdom, London
University College London
Rosenheim, Joshua
United Kingdom, London
University College London
Andrade, Catarina
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Anderson, Glenn W.
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Lee, Jack C.D.
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Williams, Rachel J.
United Kingdom, London
University College London
Williams, Charlotte A.
United Kingdom, London
University College London
Tutill, Helena J.
United Kingdom, London
University College London
Bayzid, Nadua
United Kingdom, London
University College London
Martin Bernal, Luz Marina
United Kingdom, London
University College London
Macpherson, Hannah
United Kingdom, London
University College London
Montgomery, Kylie Ann
United Kingdom, London
University College London
Moore, Catherine
United Kingdom, Cardiff
Public Health Wales
Templeton, Kate E.
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Neill, Claire
United Kingdom, Belfast
Public Health Agency
Holden, Matthew T.G.
United Kingdom, St Andrews
University of st Andrews
United Kingdom, Edinburgh
Public Health Scotland
Gunson, Rory N.
United Kingdom, Glasgow
West of Scotland Specialist Virology Centre
Shepherd, Samantha J.
United Kingdom, Glasgow
West of Scotland Specialist Virology Centre
Shah, Priyen
United Kingdom, London
Imperial College London
Cooray, Samantha
United Kingdom, London
Imperial College London
Voice, Marie
United Kingdom, Coventry
University of Warwick
Steele, Michael
United Kingdom, Coventry
University of Warwick
Fink, Colin G.
United Kingdom, Coventry
University of Warwick
Whittaker, Thomas E.
United Kingdom, London
University College London
Santilli, Giorgia
United Kingdom, London
University College London
Gissen, Paul
United Kingdom, London
University College London
Kaufer, Benedikt B.
Germany, Berlin
Freie Universität Berlin
Reich, Jana
Germany, Berlin
Freie Universität Berlin
Andréani, Julien
United Kingdom, Oxford
University of Oxford
France, Grenoble
Centre Hospitalier Universitaire de Grenoble
Simmonds, Peter
United Kingdom, Oxford
University of Oxford
Alrabiah, Dimah K.
United Kingdom, London
University College London
Saudi Arabia, Riyadh
King Abdulaziz City for Science and Technology
Castellano, Sergi
United Kingdom, London
University College London
Chikowore, Primrose
United Kingdom, Edinburgh
The University of Edinburgh
Odam, Miranda
United Kingdom, Edinburgh
The University of Edinburgh
Rampling, Tommy W.
United Kingdom, London
University College London
United Kingdom, London
Uk Health Security Agency
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Houlihan, Catherine F.
United Kingdom, London
University College London
United Kingdom, London
Uk Health Security Agency
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Höschler, Katja
United Kingdom, London
Uk Health Security Agency
Talts, Tiina
United Kingdom, London
Uk Health Security Agency
Celma, Cristina C.P.
United Kingdom, London
Uk Health Security Agency
Gonzalez, Suam
United Kingdom, London
Uk Health Security Agency
Gallagher, Eileen
United Kingdom, London
Uk Health Security Agency
Simmons, Ruth D.
United Kingdom, London
Uk Health Security Agency
Watson, Conall H.
United Kingdom, London
Uk Health Security Agency
Mandal, Sema
United Kingdom, London
Uk Health Security Agency
Zambon, Maria C.
United Kingdom, London
Uk Health Security Agency
Chand, Meera A.
United Kingdom, London
Uk Health Security Agency
Hatcher, James Christopher
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
De, Surjo
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Baillie, Kenneth J.
United Kingdom, Edinburgh
The University of Edinburgh
Semple, Malcolm Gracie
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Alder Hey Children's Hospital
Bellos, Evangelos
United Kingdom, London
Imperial College London
Broderick, Claire
United Kingdom, London
Imperial College London
Channon-Wells, Samuel William
United Kingdom, London
Imperial College London
De, Tisham
United Kingdom, London
Imperial College London
D’Souza, Giselle
United Kingdom, London
Imperial College London
Elorrieta, Leire Estramiana
United Kingdom, London
Imperial College London
Estrada-Rivadeneyra, Diego
United Kingdom, London
Imperial College London
Galassini, Rachel
United Kingdom, London
Imperial College London
Habgood-Coote, Dominic
United Kingdom, London
Imperial College London
Hamilton, Shea
United Kingdom, London
Imperial College London
Jackson, Heather R.
United Kingdom, London
Imperial College London
Kavanagh, James
United Kingdom, London
Imperial College London
Marjaneh, Mahdi Moradi
United Kingdom, London
Imperial College London
Menikou, Stephanie
United Kingdom, London
Imperial College London
Nichols, Samuel J.
United Kingdom, London
Imperial College London
Nijman, Ruud Gerard
United Kingdom, London
Imperial College London
United Kingdom, London
St Mary's Hospital
Patel, Harsita
United Kingdom, London
Imperial College London
Pennisi, Ivana
United Kingdom, London
Imperial College London
Powell, Oliver
United Kingdom, London
Imperial College London
Reid, Ruth
United Kingdom, London
Imperial College London
Vito, Ortensia
United Kingdom, London
Imperial College London
Whittaker, Elizabeth A.
United Kingdom, London
Imperial College London
Wilson, Clare M.
United Kingdom, London
Imperial College London
Womersley, Rebecca S.
United Kingdom, London
Imperial College London
Abdulla, Amina F.
United Kingdom, London
St Mary's Hospital
Darnell, Sarah
United Kingdom, London
St Mary's Hospital
Mustafa, Sobia
United Kingdom, London
St Mary's Hospital
Georgiou, Pantelis
United Kingdom, London
Imperial College London
Moser, Nicolas
United Kingdom, London
Imperial College London
Carter, Michael J.
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
United Kingdom, London
King's College London
Tibby, Shane M.
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
United Kingdom, London
King's College London
Kenny, Julia M.
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Wellman, Paul A.
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Fidler, Katy J.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Agranoff, Daniel D.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Richmond, Vivien
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Faust, Saul N.
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Southampton
University of Southampton
Liebeschuetz, Susan
United Kingdom, London
Newham University Hospital
Riddell, Anna C.
United Kingdom, London
The Royal London Hospital
Peters, Mark John
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Bamford, A. R.J.
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
United Kingdom, London
University College London
Pathan, Nazima
United Kingdom, Cambridge
Addenbrooke's Hospital
United Kingdom, Cambridge
University of Cambridge
White, Deborah K.
United Kingdom, Cambridge
Addenbrooke's Hospital
Heightman, Melissa J.
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Drysdale, Simon Bruce
United Kingdom, London
St George's Hospital
Moots, Robert John
United Kingdom, Liverpool
Aintree University Hospital
Deep, Akash
United Kingdom, London
King's College Hospital
Gormley, Stuart
United Kingdom, Sheffield
Sheffield Children's Hospital
Pollard, Andrew J.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Shrestha, Shrijana R.
Nepal, Kathmandu
Patan Academy of Health Sciences
Gurung, Meeru
Nepal, Kathmandu
Patan Academy of Health Sciences
Pokhrel, Bhishma R.
Nepal, Kathmandu
Patan Academy of Health Sciences
Bijukchhe, Sanjeev Man
Nepal, Kathmandu
Patan Academy of Health Sciences
Martinón-Torres, Federico
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Salas, Antonio
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
González, Fernando Álvez
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Bello, Xabier
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Carnota, Sandra
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Cebey-López, Miriam
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Currás-Tuala, María José
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Suárez, Carlos Durán
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Vicente, Luisa García
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Gõmez-Carballa, Alberto
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Rial, Jose Gómez
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Iglesias, Pilar Leboráns
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Martinón-Torres, Nazareth
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Sánchez, José María
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Pérez, Belén Mosquera
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Pardo-Seco, Jacobo
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Pischedda, Sara
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Calle, Irene Rivero
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Rodríguez-Tenreiro, Carmen
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Redondo Collazo, Lorenzo
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Fernández, Sonia Serén
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Carrol, Enitan D.
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Alder Hey Children's Hospital
United Kingdom, Liverpool
Liverpool Health Partners
Khanijau, Aakash
United Kingdom, Liverpool
University of Liverpool
Romaine, Sam T.
United Kingdom, Liverpool
University of Liverpool
Tsolia, Maria N.
Greece, Athens
Aghia Sophia Children's Hospital
Eleftheriou, Irini
Greece, Athens
Aghia Sophia Children's Hospital
Spyridis, Nikos P.
Greece, Athens
Aghia Sophia Children's Hospital
Maritsi, Despoina N.
Greece, Athens
Aghia Sophia Children's Hospital
Emonts, Marieke
United Kingdom, Newcastle
Newcastle University
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Lim, Emma J.
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
United Kingdom, Newcastle
Newcastle University
Isaacs, John D.
United Kingdom, Newcastle
Newcastle University
van der Velden, Fabian Johannes Stanislaus
United Kingdom, Newcastle
Newcastle University
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Rojo, Pablo
Spain, Madrid
Servicio Madrileño de Salud
Spain, Madrid
Universidad Complutense de Madrid
Epalza, Cristina
Spain, Madrid
Servicio Madrileño de Salud
Spain, Madrid
Instituto de Investigación Hospital 12 de Octubre
Kuijpers, Taco W.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Sanquin Research
van Furth, Marceline Tutu
Netherlands, Amsterdam
Universiteit Van Amsterdam
Pajkrt, Dasja
Netherlands, Amsterdam
Universiteit Van Amsterdam
van Hensbroek, Michael Boele
Netherlands, Amsterdam
Universiteit Van Amsterdam
Romani, Lorenza
Italy, Rome
Irccs Ospedale Pediatrico Bambino Gesù
Luca, Maia De
Italy, Rome
Irccs Ospedale Pediatrico Bambino Gesù
Chiurchiù, Sara
Italy, Rome
Irccs Ospedale Pediatrico Bambino Gesù
Vermont, Clementien L.
Netherlands, Rotterdam
Erasmus Mc
Moll, Henriëtte A.
Netherlands, Rotterdam
Erasmus Mc
Hagedoorn, Nienke N.
Netherlands, Rotterdam
Erasmus Mc
Dik, Willem Arnout
Netherlands, Rotterdam
Erasmus Mc
Shen, Chingfen
United Kingdom, London
Imperial College London
Taiwan, Tainan
National Cheng Kung University
Zavadska, Dace
Latvia, Riga
Riga Stradins University
Latvia, Riga
Bērnu Klīniskā Universitātes Slimnīca
Rudzate, Aleksandra
Latvia, Riga
Riga Stradins University
Latvia, Riga
Bērnu Klīniskā Universitātes Slimnīca
Mommert-Tripon, Marine
France, Marcy-l'etoile
Biomérieux sa
Brengel-Pesce, Karen
France, Marcy-l'etoile
Biomérieux sa
France, Lyon
Chu de Lyon
France, Lyon
Université de Lyon
Pokorn, Marko
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Slovenia, Ljubljana
Univerza V Ljubljani
Kolnik, Mojca
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Avĉin, Tadej
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Slovenia, Ljubljana
Univerza V Ljubljani
Vincek, Katarina
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
van der Flier, Michiel
Netherlands, Utrecht
University Medical Center Utrecht
Netherlands, Utrecht
Princess Máxima Center for Pediatric Oncology
Netherlands, Nijmegen
Radboud University Medical Center
Wösten-van Asperen, Roelie M.
Netherlands, Utrecht
University Medical Center Utrecht
Vastert, Bas J.
Netherlands, Utrecht
University Medical Center Utrecht
Bont, Louis J.
Netherlands, Utrecht
University Medical Center Utrecht
Netherlands, Utrecht
Princess Máxima Center for Pediatric Oncology
Beudeker, Coco R.
Netherlands, Utrecht
University Medical Center Utrecht
Netherlands, Utrecht
Princess Máxima Center for Pediatric Oncology
Agyeman, Philipp Kwame Abayie
Switzerland, Bern
University of Bern
Schlapbach, Luregn J.
Switzerland, Zurich
Kinderspital Zürich
Australia, Brisbane
The University of Queensland
Pósfay-Barbe, Klara Maria
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Heininger, Ulrich
Switzerland, Basel
Universitat Basel
Kahlert, Christian R.
Switzerland, St Gallen
Children's Hospital of Eastern Switzerland
Riedel, Thomas
Unknown Affiliation
Berger, Christoph Tobias
Switzerland, Zurich
Kinderspital Zürich
Calvo-Bado, Leo A.
United Kingdom, Coventry
University of Warwick
Zenz, Werner M.
Austria, Graz
Medizinische Universität Graz
Binder, Alexander
Austria, Graz
Medizinische Universität Graz
Kohlmaier, Benno
Austria, Graz
Medizinische Universität Graz
Kohlfürst, Daniela S.
Austria, Graz
Medizinische Universität Graz
Schweintzger, Nina Alexandra
Austria, Graz
Medizinische Universität Graz
Sagmeister, Manfred G.
Austria, Graz
Medizinische Universität Graz
Benesch, Martin
Austria, Graz
Medizinische Universität Graz
Eber, Ernst
Austria, Graz
Medizinische Universität Graz
van Keulen, Daniëlle
Unknown Affiliation
von Both, Ulrich
Germany, Munich
Ludwig-maximilians-universität München
Germany, Munich
Partner Site Munich
Kolberg, Laura
Germany, Munich
Ludwig-maximilians-universität München
Danhauser, Katharina
Germany, Munich
Ludwig-maximilians-universität München
Hoffmann, Florian
Germany, Munich
Ludwig-maximilians-universität München
Griese, Matthias
Germany, Munich
Ludwig-maximilians-universität München
Feuchtinger, Tobias
Germany, Munich
Ludwig-maximilians-universität München
Lurz, Eberhard
Germany, Munich
Ludwig-maximilians-universität München
Maier, Esther Maria
Germany, Munich
Ludwig-maximilians-universität München
Reiter, Karl
Germany, Munich
Ludwig-maximilians-universität München
Yeung, Shunmay M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
United Kingdom, London
St Mary's Hospital
Bath, David
United Kingdom, London
London School of Hygiene & Tropical Medicine
Fitchett, Elizabeth J.A.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Cresswell, Fiona Valarie
United Kingdom, London
London School of Hygiene & Tropical Medicine
Cunnington, Aubrey J.
United Kingdom, London
Imperial College London
Herberg, Jethro Adam
United Kingdom, London
Imperial College London
Kaforou, Myrsini
United Kingdom, London
Imperial College London
Baumard, Lucas
United Kingdom, London
Imperial College London
Hoggart, Clive J.
United Kingdom, London
Imperial College London
Hourmat, Sara
United Kingdom, London
Imperial College London
Maconochie, Ian
United Kingdom, London
Imperial College London
Lin, Naomi
United Kingdom, London
Imperial College London
Paz, Ivonne Pena
United Kingdom, London
Imperial College London
Ali, Ladan
United Kingdom, London
St Mary's Hospital
Jorgensen, Rikke
United Kingdom, London
St Mary's Hospital
Persand, Salina
United Kingdom, London
St Mary's Hospital
Stevens, Molly M.
United Kingdom, London
Imperial College London
Kim, Eunjung
United Kingdom, London
Imperial College London
Pierce, Benjamin
United Kingdom, London
Imperial College London
Dudley, Julia R.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Tavliavini, Emma
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Liu, Chingchuan
Taiwan, Tainan
National Cheng Kung University
Wang, Shihmin
Taiwan, Tainan
National Cheng Kung University
Farto, Cristina Balo
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Barral-Arca, Ruth
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Castro, María Barreiro
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Usuf, Effua Abigail
United Kingdom, London
London School of Hygiene & Tropical Medicine
Bojang, Kalifa A.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Zaman, Syed M.A.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Secka, Fatou
United Kingdom, London
London School of Hygiene & Tropical Medicine
Anderson, Suzanne T.B.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Darboe, Saffiatou
United Kingdom, London
London School of Hygiene & Tropical Medicine
Ceesay, Samba
United Kingdom, London
London School of Hygiene & Tropical Medicine
D‘Alessandro, Umberto
United Kingdom, London
London School of Hygiene & Tropical Medicine
Paulus, Stéphane C.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
United Kingdom, Liverpool
University of Liverpool
Jennings, Rebecca J.
United Kingdom, Liverpool
Alder Hey Children's Hospital
Sperl, Matthias
Austria, Graz
Medizinische Universität Graz
Till, Holger Karl H.
Austria, Graz
Medizinische Universität Graz
Trobisch, Andreas
Austria, Graz
Medizinische Universität Graz
Dewez, Juan Emmanuel
United Kingdom, London
London School of Hygiene & Tropical Medicine
Hibberd, Martin Lloyd
United Kingdom, London
London School of Hygiene & Tropical Medicine
Miners, Alec H.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Wedderburn, Catherine J.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Leurent, Baptiste
United Kingdom, London
London School of Hygiene & Tropical Medicine
de Groot, Ronald C.A.
Netherlands, Nijmegen
Radboud University Medical Center
de Jonge, Marien Isaäk
Netherlands, Utrecht
University Medical Center Utrecht
van Aerde, Koen J.
Netherlands, Nijmegen
Radboud University Medical Center
Alkema, Wynand B.L.
Netherlands, Nijmegen
Radboud University Medical Center
Philipsen, Ria La
Netherlands, Nijmegen
Radboud University Medical Center
Obihara, Charlie C.C.
Unknown Affiliation
Kandasamy, Rama
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Bibi, Sagida
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Kelly, Dominic F.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Murdoch, David Roger
New Zealand, Christchurch
University of Otago, Christchurch
Agbeko, Rachel Sarah
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Martin, Alexander James
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
de Vries, Gabriella
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Bidlingmaier, Christoph M.
Germany, Munich
Ludwig-maximilians-universität München
Mallet, François
France, Marcy-l'etoile
Biomérieux sa
France, Lyon
Chu de Lyon
France, Lyon
Université de Lyon
Pachot, Alexandre
France, Marcy-l'etoile
Biomérieux sa
Mommert, Marine
France, Marcy-l'etoile
Biomérieux sa
France, Lyon
Chu de Lyon
Barendregt, Anouk Marinke
Netherlands, Amsterdam
Universiteit Van Amsterdam
van der Kuip, Martijn
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Van Furth, A. M.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
van Mierlo, Gerard J.
Netherlands, Amsterdam
Sanquin Research
Carson, Gail Lindsay
United Kingdom, Oxford
University of Oxford
Openshaw, Peter J.M.
United Kingdom, London
Imperial College London
United Kingdom, London
Imperial College Healthcare Nhs Trust
Dunning, Jake W.
United Kingdom, London
Imperial College London
United Kingdom, London
Public Health England
Merson, Laura
United Kingdom, Oxford
University of Oxford
Russell, Clark Donald
United Kingdom, Edinburgh
University of Edinburgh, College of Medicine and Veterinary Medicine
Tedder, Richard S.
United Kingdom, London
Public Health England
United Kingdom, Bristol
Nhs Blood and Transplant
United Kingdom, London
Imperial College London
Turtle, Lance C.W.
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Liverpool
Royal Liverpool University Hospital
Solomon, Tom
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Liverpool
The Walton Centre Nhs Foundation Trust
Ijaz, Samreen
United Kingdom, London
Public Health England
Fletcher, Tom E.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Palmarini, Massimo
United Kingdom, London
Medical Research Council
Ho, Antonia Yw
United Kingdom, London
Medical Research Council
Price, Nicholas Martin
United Kingdom, London
King's College London
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
de Silva, Thushan I.
United Kingdom, Sheffield
The University of Sheffield
Donohue, Chloe
United Kingdom, Liverpool
University of Liverpool
Hardwick, Hayley E.
United Kingdom, Royston
National Institute for Health and Care Research
Oosthuyzen, Wilna
United Kingdom, London
Uk Health Security Agency
Clohisey, Sara M.R.
United Kingdom, London
Uk Health Security Agency
Law, Andrew S.
United Kingdom, London
Uk Health Security Agency
Fawkes, Angie
Unknown Affiliation
Gilchrist, Tammy
Unknown Affiliation
Murphy, Lee D.
Unknown Affiliation
Wrobel, Nicola
Unknown Affiliation
Henderson, Paul M.
United Kingdom, Edinburgh
Nhs Lothian
Pollock, Louisa
United Kingdom, Glasgow
Royal Hospital for Children, Glasgow
Brotherton, Helen
United Kingdom, Dunfermline
Queen Margaret Hospital
United Kingdom, Kirkcaldy
Victoria Hospital Kirkcaldy
Fullerton, Duncan G.
United Kingdom, Crewe
Leighton Hospital
McGill, Fiona
United Kingdom, Leeds
Leeds Teaching Hospitals Nhs Trust
Collins, Emma L.
Unknown Affiliation
Ushiro-Lumb, Inês
United Kingdom, Bristol
Nhs Blood and Transplant
Noursadeghi, Mahdad
United Kingdom, London
University College London
Grammatikopoulos, Tassos
United Kingdom, London
King's College Hospital
Brown, Rachel Mary
United Kingdom, Birmingham
University Hospitals Birmingham Nhs Foundation Trust
Waddington, Simon N.
United Kingdom, London
University College London
South Africa, Tygerberg
South African Medical Research Council
Jacques, Thomas Stanley
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
United Kingdom, London
University College London
Thomson, Emma C.
United Kingdom, London
Medical Research Council
Levin, Michael L.
United Kingdom, London
Imperial College London
Brown, Julianne Rose
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Breuer, Judith M.
United Kingdom, London
University College London
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Statistics
Citations: 47
Authors: 314
Affiliations: 146
Identifiers
Doi:
10.1038/s41586-023-06003-w
ISSN:
00280836
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health