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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of laser resurfacing on p53 expression in photoaged facial skin
Dermatologic Surgery, Volume 33, No. 6, Year 2007
Notification
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Description
BACKGROUND: p53 overexpression has been reported in photoaged skin. Meanwhile, p53 gene mutations have been implicated as an important factor in the pathogenesis of ultraviolet (UV) light-induced skin cancer. OBJECTIVE: The objective was to evaluate the effect of laser resurfacing on the epidermal thickness and expression of p53 in photoaged skin. METHODS: Specimens were obtained from the facial skin of 10 patients before and after 3 months and 1 year of treatment using CO2 (five cases) and erbium (Er):YAG (five cases) lasers. Specimens were also obtained from six age-matched controls. These biopsies were used for routine histopathology, histometry, and p53 immunoperoxidase staining. RESULTS: Both CO2 and Er:YAG lasers were found to induce a significant decrease in p53 expression in biopsies obtained after 3 months (p=.0004 and.002, respectively) followed by gradual increase (p=.01 in both groups). A significant increase (p<.01) in epidermal thickness was also observed after 1 year of resurfacing. This increase, however, is inversely correlated with the level of p53 expression in such patients. CONCLUSION: The decrease in epidermal p53 expression after CO2 and Er:YAG lasers may account for some of the benefits of resurfacing on the epidermis, as well as prevention of actinic neoplasia by adjusting any disturbance in the proliferation/apoptosis balance observed in photoaged facial skin. © 2007 by the American Society for Dermatologic Surgery, Inc.
Authors & Co-Authors
El-Domyati, Moetaz M.M.
Egypt, Minya
Al-minya University Hospital
Egypt, Minya
Minia University
Attia, Sameh K.
Egypt, Minya
Al-minya University Hospital
Esmat, Ashraf M.
Egypt, Minya
Al-minya University Hospital
Ahmad, Hesham M.
Egypt, Minya
Al-minya University Hospital
Abdel-Wahab, Hossam
Egypt, Minya
Al-minya University Hospital
Badr, Belkais M.
Egypt, Minya
Al-minya University Hospital
Statistics
Citations: 18
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1111/j.1524-4725.2007.33141.x
ISSN:
10760512
e-ISSN:
15244725
Research Areas
Cancer
Genetics And Genomics
Health System And Policy