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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
In vivo demonstration of nitrogen-sparing mechanisms for glucose and amino acids in the injured rat
Metabolism, Volume 29, No. 2, Year 1980
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Description
Changes in protein metabolism 8 hr after anesthesia and femur fracture were studied in healthy rats fasted or receiving either intravenous glucose or crystalline amino acids. Whole body rates of amino acid turnover (flux) and release from protein (breakdown) as well as fractional synthetic rates of mixed muscle, liver, and plasma protein were measured using the constant infusion of L-(I-14C)-leucine. Injury resulted in a 24% and 63% increase in the synthesis of liver (p < 0.05) and plasma proteins (p < 0.01), respectively. Amino acid infusions in the injured animals further increased the synthesis of liver protein (from 36.6% to 44.3%/day, p < 0.05) and increased muscle protein synthesis (from 7.0% to 9.3%/day, p < 0.05) without altering rates of protein breakdown. Glucose infusions, in contrast, reduced whole body protein breakdown 36% (p < 0.05) when compared to fasting, and depleted the plasma essential amino acid pool (p < 0.05). The usual increases in liver protein synthesis observed in fasted rats following injury were not seen when the animals were receiving intravenous glucose. The nitrogen-sparing mechanism of these two infusions are different. Protein-free glucose infusions impair the normal response to injury aimed at increasing visceral protein synthesis and maintaining plasma essential amino acid concentrations. © 1980.
Authors & Co-Authors
Moldawer, Lvle L.
United States, Boston
Beth Israel Deaconess Medical Center
O'Keefe, S. J.
United States, Boston
Beth Israel Deaconess Medical Center
Statistics
Citations: 69
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1016/0026-0495(80)90143-2
ISSN:
00260495
Research Areas
Violence And Injury