Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
Nature Genetics, Volume 43, No. 10, Year 2011
Notification
URL copied to clipboard!
Description
We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and 14,458 controls drawn from studies in London, Pakistan and Singapore. We identified 20 independent SNPs associated with T2D at P < 10 -4 for testing in a replication sample of 13,170 cases and 25,398 controls, also all of South Asian ancestry. In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10 -8 to P = 1.9 × 10 -11). SNPs at GRB14 were also associated with insulin sensitivity (P = 5.0 × 10 -4), and SNPs at ST6GAL1 and HNF4A were also associated with pancreatic beta-cell function (P = 0.02 and P = 0.001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D. © 2011 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Kooner, Jaspal Singh
United Kingdom, London
National Heart and Lung Institute
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
United Kingdom, London
Imperial College Healthcare Nhs Trust
Saleheen, Danish
Pakistan, Karachi
Center for Non-communicable Diseases Pakistan
United Kingdom, Cambridge
University of Cambridge
Sim, Xueling
Singapore, Singapore City
National University of Singapore
Sehmi, Joban S.
United Kingdom, London
National Heart and Lung Institute
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Zhang, Weihua
United Kingdom, London
Imperial College London
Frossard, Philippe M.
Pakistan, Karachi
Center for Non-communicable Diseases Pakistan
Been, Latonya F.
United States, Oklahoma City
University of Oklahoma Health Sciences Center
Chia, Kee Seng
Singapore, Singapore City
National University of Singapore
Dimas, Antigone S.
Switzerland, Geneva
Université de Genève Faculté de Médecine
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Hassanali, Neelam
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Jafar, Tazeen Hasan
Pakistan, Karachi
The Aga Khan University
Pakistan, Karachi
The Aga Khan University Hospital
Jowett, Jeremy B.M.
Australia, Melbourne
Baker Heart and Diabetes Institute
Li, Xinzhong
United Kingdom, London
National Heart and Lung Institute
Radha, Venkatesan
India, New Delhi
Indian Council of Medical Research
Rees, Simon D.R.
United Kingdom, Birmingham
University of Birmingham
United Kingdom, Birmingham
University Hospitals Birmingham Nhs Foundation Trust
Takeuchi, Fumihiko
Japan, Tokyo
National Center for Global Health and Medicine
Young, Robin D.
United Kingdom, Cambridge
University of Cambridge
Aung, Tin
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Singapore Eye Research Institute
Basit, Abdul
Pakistan, Karachi
Baqai Medical University
Chidambaram, Manickam
India, New Delhi
Indian Council of Medical Research
Das, Debashish
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Grundberg, Elin
United Kingdom, London
King's College London
Hedman, Åsa K.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Zafar Iqbal, S. M.
Pakistan, Karachi
Baqai Medical University
Islam, Md Tariqul
Pakistan, Karachi
The Aga Khan University
Khor, Chiea Chuen
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Singapore Eye Research Institute
Singapore, Singapore City
A-star, Genome Institute of Singapore
Kowlessur, Sudhir
Mauritius, Port Louis
Ministry of Health
Kristensen, Malene Maag
Australia, Melbourne
Baker Heart and Diabetes Institute
Liju, Samuel
India, New Delhi
Indian Council of Medical Research
Lim, Wei Yen
Singapore, Singapore City
National University of Singapore
Matthews, David Richard Md Dphil
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Liu, Jianjun
Singapore, Singapore City
A-star, Genome Institute of Singapore
Morris, Andrew Paul
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Nica, Alexandra C.
Switzerland, Geneva
Université de Genève Faculté de Médecine
Pinidiyapathirage, Janani
Sri Lanka, Kelaniya
University of Kelaniya
Prokopenko, Inga I.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Rasheed, Asif
Pakistan, Karachi
Center for Non-communicable Diseases Pakistan
Samuel, Maria
Pakistan, Karachi
Center for Non-communicable Diseases Pakistan
Shah, Nabi
Pakistan, Karachi
Center for Non-communicable Diseases Pakistan
Shera, Abdul Samad
Pakistan, Karachi
Pakistan Pediatric Association
Small, Kerrin S.
United Kingdom, London
King's College London
United Kingdom, London
Wellcome Trust
Suo, Chen
Singapore, Singapore City
National University of Singapore
Wickramasinghe, Ananda Rajitha
Sri Lanka, Kelaniya
University of Kelaniya
Wong, Tienyin
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Singapore Eye Research Institute
Australia, Melbourne
University of Melbourne
Yang, Mingyu
China, Shenzhen
Bgi-shenzhen
Zhang, Fan
China, Shenzhen
Bgi-shenzhen
Abecasis, Gonçalo R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Barnett, Anthony H.
United Kingdom, Birmingham
University of Birmingham
United Kingdom, Birmingham
University Hospitals Birmingham Nhs Foundation Trust
Caulfield, Mark J.
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Deloukas, Panos
United Kingdom, London
Wellcome Trust
Frayling, Tim M.
United Kingdom, Exeter
University of Exeter
Froguel, Philippe
United Kingdom, London
Hammersmith Hospital
Kato, Norihiro
Japan, Tokyo
National Center for Global Health and Medicine
Katulanda, Prasad
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Sri Lanka, Colombo
University of Colombo
Kelly, Marilyn Ann
United Kingdom, Birmingham
University of Birmingham
United Kingdom, Birmingham
University Hospitals Birmingham Nhs Foundation Trust
Liang, Junbin
China, Shenzhen
Bgi-shenzhen
Mohan, Viswanathan Krishna
India, New Delhi
Indian Council of Medical Research
India, Chennai
Dr. Mohan Diabetes Specialties Centre No.6-b
Sanghera, Dharambir Kaur
United States, Oklahoma City
University of Oklahoma Health Sciences Center
Scott, James M.
United Kingdom, London
National Heart and Lung Institute
Seielstad, Mark
United States, San Francisco
University of California, San Francisco
Zimmet, Paul Z.
Australia, Melbourne
Baker Heart and Diabetes Institute
Elliott, Paul E.
United Kingdom, London
Imperial College London
United Kingdom, London
Medical Research Council
Teo, Yik Ying
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
A-star, Genome Institute of Singapore
McCarthy, Mark I.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
University of Oxford Medical Sciences Division
United Kingdom, Oxford
Churchill Hospital
Danesh, John N.
United Kingdom, Cambridge
University of Cambridge
Tai, E. Shyong
Singapore, Singapore City
National University of Singapore
Chambers, John Campbell
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
United Kingdom, London
Imperial College Healthcare Nhs Trust
United Kingdom, London
Imperial College London
Statistics
Citations: 534
Authors: 67
Affiliations: 37
Identifiers
Doi:
10.1038/ng.921
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study