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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
psychology
A Pilot Study of the Neuropsychological Benefits of Computerized Cognitive Rehabilitation in Ugandan Children With HIV
Neuropsychology, Volume 24, No. 5, Year 2010
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Description
Objective: Because antiretroviral treatment (ART) fails to improve neurocognitive impairment in children with HIV, we completed a pilot study evaluating the feasibility and cognitive benefit of computerized cognitive rehabilitation therapy (CCRT) in Ugandan children with HIV. Method: Sixty Ugandan children with HIV (23 on ART) were randomly assigned to 10 sessions of Captain's Log CCRT (Sandford, 2007) training configured for attention and memory skills or no intervention. Kaufman Assessment Battery for Children (2nd ed., KABC-2; Kaufman & Kaufman, 2004) performance at baseline indicated pervasive neurocognitive impairment. Cognitive ability was assessed before and after training using the Cogstate computerized neuropsychological test (Darby, Maruff, Collie, & McStephen, 2002). Viral load along with CD4 and CD8 absolute and activation levels also were measured posttest. Results: CCRT was well received with a 95% adherence rate to scheduled training sessions. CCRT intervention children showed greater improvement on a Cogstate card detection task of simple attention (p = .02), and speed of correct moves on a Groton Maze Learning Task (p < .001). These analyses were completed using an analysis of covariance model that adjusted Cogstate performance for the child's age, standardized weight for age, gender, socioeconomic status, school grade level, and baseline KABC-2 performance. ART treatment was not related to Cogstate performance or improvement as a result of CCRT. CD4 and CD8 activation levels were correlated with Cogstate improvement specifically for the CCRT group. Conclusions: CCRT was feasible with our study population and improved maze learning and attention on a detection task. This supports previous findings by our group with cerebral malaria survivors (Bangirana, Giordani, et al., 2009). © 2010 American Psychological Association.
Authors & Co-Authors
Boivin, Michael Joseph
United States, East Lansing
Michigan State University
United States, Ann Arbor
University of Michigan, Ann Arbor
Busman, Rachelle A.
United States, East Lansing
Michigan State University
Parikh, Sujal M.
United States, Ann Arbor
University of Michigan, Ann Arbor
Bangirana, Paul
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Page, Connie Faye
United States, East Lansing
Michigan State University
Opoka, Robert Opika
Uganda, Kampala
Mulago Hospital
Giordani, Bruno J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Statistics
Citations: 115
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1037/a0019312
ISSN:
08944105
e-ISSN:
19311559
Research Areas
Disability
Infectious Diseases
Maternal And Child Health
Mental Health
Study Design
Randomised Control Trial
Cross Sectional Study