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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Epidemiological and molecular features of dengue virus type-1 in New Caledonia, South Pacific, 2001-2013
Virology Journal, Volume 11, No. 1, Article 61, Year 2014
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Description
Background: The epidemiology of dengue in the South Pacific has been characterized by transmission of a single dominant serotype for 3-5 years, with subsequent replacement by another serotype. From 2001 to 2008 only DENV-1 was reported in the Pacific. In 2008, DENV-4 emerged and quickly displaced DENV-1 in the Pacific, except in New Caledonia (NC) where DENV-1 and DENV-4 co-circulated in 2008-2009. During 2012-2013, another DENV-1 outbreak occurred in NC, the third DENV-1 outbreak in a decade. Given that dengue is a serotype-specific immunizing infection, the recurrent outbreaks of a single serotype within a 10-year period was unexpected. Findings. This study aimed to inform this phenomenon by examining the phylogenetic characteristics of the DENV-1 viruses in NC and other Pacific islands between 2001 and 2013. As a result, we have demonstrated that NC experienced introductions of viruses from both the Pacific (genotype IV) and South-east Asia (genotype I). Moreover, whereas genotype IV and I were co-circulating at the beginning of 2012, we observed that from the second half of 2012, i.e. during the major DENV-1 outbreak, all analyzed viruses were genotype I suggesting that a genotype switch occurred. Conclusions: Repeated outbreaks of the same dengue serotype, as observed in NC, is uncommon in the Pacific islands. Why the earlier DENV-1 outbreaks did not induce sufficient herd immunity is unclear, and likely multifactorial, but the robust vector control program may have played a role by limiting transmission and thus maintaining a large susceptible pool in the population. © 2014 Dupont-Rouzeyrol et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Dupont-Rouzeyrol, Myrielle
New Caledonia, Noumea
Institut Pasteur de Nouvelle-caledonie Noumea
O'Connor, Olivia
New Caledonia, Noumea
Institut Pasteur de Nouvelle-caledonie Noumea
Gourinat, Ann Claire
New Caledonia, Noumea
Institut Pasteur de Nouvelle-caledonie Noumea
Guigon, Aurélie
New Caledonia, Noumea
Institut Pasteur de Nouvelle-caledonie Noumea
Nilles, Eric J.
Switzerland, Geneva
Organisation Mondiale de la Santé
Chanteau, Suzanne
New Caledonia, Noumea
Institut Pasteur de Nouvelle-caledonie Noumea
Aaskov, John G.
Australia, Brisbane
Queensland University of Technology
Cao-Lormeau, Van Mai
Unknown Affiliation
Statistics
Citations: 36
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1186/1743-422X-11-61
ISSN:
1743422X
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study