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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Parity and mortality in cases of childhood-onset diabetes mellitus
Diabetes/Metabolism Research and Reviews, Volume 32, No. 6, Year 2016
Notification
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Description
Aims: This study aims to assess the association between parity and mortality in adults with childhood-onset type 1 diabetes (T1D) and their matched controls. Methods: Individual data (308 617 person-years) on mortality and the reproductive histories of a Finnish cohort of 2307 women and 2819 men with T1D, each with two matched controls, were obtained from the National Population Register. All persons with diabetes had been diagnosed with T1D in 1965–1979 at the age of 17 or under. Results: All-cause mortality in people without offspring was significantly higher than that in people with children among both people with diabetes and non-diabetic control persons in both sexes (all p-values <0.01). In men with offspring, the decrease of mortality rate compared with men without offspring was less marked among those with diabetes (9% reduction in mortality hazard ratio (HR) with one offspring, 47% with two) than among those without diabetes (33% HR (p = 0.025) and 61% HR (p = 0.023) reduction, respectively). In women with offspring, the association between parity and mortality was independent of diabetes status. Having at least two offspring was associated with a decreased hazard of diabetes-related death regardless of sex; among women with diabetes, even having one offspring was associated with a decreased hazard of dying from diabetes (HR = 0.46; 95% CI 0.31, 0.69). Conclusions: The association between parity and mortality follows different patterns in men and women with T1D. To what extent this reflects effects of health on family planning decisions in people with T1D cannot be defined without further studies. Copyright © 2016 John Wiley & Sons, Ltd.
Authors & Co-Authors
Sjöberg, Lena
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
National Institute of Health and Welfare
He, Liang
Finland, Helsinki
Helsingin Yliopisto
Kaaja, Risto Juhani
Finland, Turku
Turun Yliopistollinen Keskussairaala
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Helsingin Yliopisto
Austria, Krems an Der Donau
Donau-universität Krems
Saudi Arabia, Jeddah
King Abdulaziz University
Pitkäniemi, Janne M.
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
Suomen Syöpärekisteri
Statistics
Citations: 5
Authors: 5
Affiliations: 6
Identifiers
Doi:
10.1002/dmrr.2778
ISSN:
15207552
Research Areas
Environmental
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female