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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Rare and low-frequency coding variants alter human adult height
Nature, Volume 542, No. 7640, Year 2017
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Description
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Authors & Co-Authors
Marouli, Eirini
United Kingdom, London
Queen Mary University of London
Graff, Misa E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Medina-Gõmez, Carolina
Netherlands, Rotterdam
Erasmus Mc
Wood, Andrew R.
United Kingdom, Exeter
University of Exeter
Fine, Rebecca S.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Boston Children's Hospital
Lu, Yingchang
United States, Nashville
Vanderbilt University School of Medicine
United States, New York
Icahn School of Medicine at Mount Sinai
Schurmann, Claudia
United States, New York
Icahn School of Medicine at Mount Sinai
Highland, Heather M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Houston
University of Texas Health Science Center at Houston
Rueger, Sina
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Thorleifsson, Gudmar
Iceland, Reykjavik
Decode Genetics
Justice, Anne E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lamparter, David
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Lausanne
Université de Lausanne Unil
Stirrups, Kathleen E.
United Kingdom, London
Queen Mary University of London
United Kingdom, Cambridge
University of Cambridge
Turcot, Valérie
Canada, Montreal
Institut de Cardiologie de Montreal
Young, Kristin L.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Winkler, Thomas W.
Germany, Regensburg
Universität Regensburg
Esko, Tönu
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Boston Children's Hospital
Estonia, Tartu
Tartu Ülikool
Karaderi, Tugce
United Kingdom, Oxford
University of Oxford
Locke, Adam E.
United States, Ann Arbor
University of Michigan School of Public Health
United States, St. Louis
Washington University School of Medicine in St. Louis
Masca, Nicholas G.D.
United Kingdom, Leicester
Glenfield Hospital
Ng, Maggie Chor Yin
United States, Winston Salem
Wake Forest University School of Medicine
Mudgal, Poorva
United States, Winston Salem
Wake Forest University School of Medicine
Rivas, Manuel A.
United States, Cambridge
Massachusetts Institute of Technology
United Kingdom, Oxford
Nuffield Department of Medicine
Vedantam, Sailaja L.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Boston Children's Hospital
Mahajan, Anubha
United Kingdom, Oxford
University of Oxford
Guo, Xiuqing
United States, Torrance
The Lundquist Institute
Abecasis, Gonçalo R.
United States, Ann Arbor
University of Michigan School of Public Health
Aben, Katja K.H.
Netherlands, Nijmegen
Radboud University Medical Center
Adair, Linda S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Alam, Dewan Shamsul
Bangladesh, Dhaka
Centre for Control of Chronic Diseases Cccd
Albrecht, Eva
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Allin, Kristine Højgaard
Denmark, Copenhagen
Københavns Universitet
Allison, Matthew A.
United States, La Jolla
University of California, San Diego
Amouyel, Philippe
France, Paris
Inserm
France, Lille
Institut Pasteur de Lille
France, Lille
Facteurs de Risque et Déterminants Moléculaires Des Maladies Liées au Vieillissement Rid-age
Appel, Emil Vincent Rosenbaum
Denmark, Copenhagen
Københavns Universitet
Arveiler, Dominique
France, Strasbourg
Université de Strasbourg
France, Strasbourg
Les Hôpitaux Universitaires de Strasbourg
Asselbergs, Folkert W.
Netherlands, Utrecht
University Medical Center Utrecht
Netherlands, Amsterdam
Royal Netherlands Academy of Arts and Sciences - Knaw
United Kingdom, London
University College London
Auer, Paul Livermore
United States, Milwaukee
University of Wisconsin-milwaukee
Balkau, Beverley J.
France, Villejuif
Centre de Recherche en Épidémiologie et Santé Des Populations
Banas, Bernhard
Germany, Regensburg
Klinikum Der Universität Regensburg Und Medizinische Fakultät
Bang, Lia Evi
Denmark, Copenhagen
Copenhagen University Hospital
Benn, Marianne
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Bergmann, Sven Michael
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Lausanne
Université de Lausanne Unil
Bielak, Lawrence F.
United States, Ann Arbor
University of Michigan, Ann Arbor
Blüher, Matthias
Germany, Leipzig
Universität Leipzig
Boeing, Heiner
Germany, Nuthetal
German Institute of Human Nutrition
Boerwinkle, Eric A.
United States, Houston
University of Texas Health Science Center at Houston
United States, Houston
Baylor College of Medicine
Böger, Carsten Alexander
Germany, Regensburg
Klinikum Der Universität Regensburg Und Medizinische Fakultät
Bonnycastle, Lori L.C.
United States, Bethesda
National Institutes of Health Nih
Bork-Jensen, Jette
Denmark, Copenhagen
Københavns Universitet
Bots, Michiel L.
Netherlands, Utrecht
University Medical Center Utrecht
Böttinger, Erwin P.
United States, New York
Icahn School of Medicine at Mount Sinai
Bowden, Donald W.
United States, Winston Salem
Wake Forest University School of Medicine
Brandslund, Ivan
Denmark, Vejle
Sygehus Lillebælt - Vejle
Denmark, Odense
Syddansk Universitet
Breen, Gerome D.
United Kingdom, London
Faculty of Life Sciences & Medicine
Brilliant, Murray H.
United States, Marshfield
Marshfield Clinic
Broer, Linda
Netherlands, Rotterdam
Erasmus Mc
Burt, Amber A.
United States, Seattle
University of Washington
Butterworth, Adam S.
United Kingdom, Cambridge
University of Cambridge
Carey, David J.
United States, Danville
Weis Center for Research
Caulfield, Mark J.
United Kingdom, London
Queen Mary University of London
Chambers, John Campbell
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
United Kingdom, London
Imperial College London
United Kingdom, London
Imperial College Healthcare Nhs Trust
Chasman, Daniel I.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
Chen, Yii Der Ida
United States, Torrance
The Lundquist Institute
Chowdhury, Rajiv H.
United Kingdom, Cambridge
University of Cambridge
Christensen, Cramer Kjeldahl
Denmark, Vejle
Sygehus Lillebælt - Vejle
Chu, Audrey Y.
United States, Boston
Harvard Medical School
United States, Framingham
Framingham Heart Study
Cocca, Massimiliano
Italy, Trieste
Università Degli Studi Di Trieste
Collins, Francis S.
United States, Bethesda
National Institutes of Health Nih
Cook, James P.
United Kingdom, Liverpool
University of Liverpool
Corley, Janie
United Kingdom, Edinburgh
The University of Edinburgh
Cox, Amanda Julie
United States, Winston Salem
Wake Forest University School of Medicine
Australia, Brisbane
Griffith University
Cuellar-Partida, Gabriel
Australia, Brisbane
The University of Queensland
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Danesh, John N.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, London
British Heart Foundation
Davies, Gail
United Kingdom, Edinburgh
The University of Edinburgh
de Bakker, Paul I.W.
Netherlands, Utrecht
University Medical Center Utrecht
de Borst, Gert Jan
Netherlands, Utrecht
University Medical Center Utrecht
de Denus, Simon
Canada, Montreal
Institut de Cardiologie de Montreal
Canada, Montreal
University of Montreal
de Mutsert, Renée
Netherlands, Leiden
Leids Universitair Medisch Centrum
Deary, Ian J.
United Kingdom, Edinburgh
The University of Edinburgh
Dedoussis, George V.Z.
Greece, Athens
Harokopio University of Athens
Demerath, Ellen W.
United States, Minneapolis
University of Minnesota Twin Cities
Den Hollander, Anneke I.
Netherlands, Nijmegen
Radboud University Medical Center
Dennis, Joe G.
United Kingdom, Cambridge
University of Cambridge
Di Angelantonio, Emanuele
United Kingdom, Cambridge
University of Cambridge
Drenos, Fotios
United Kingdom, London
University College London
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Du, Mengmeng
United States, Seattle
Fred Hutchinson Cancer Center
United States, New York
Memorial Sloan-kettering Cancer Center
Dunning, Alison M.
United Kingdom, Cambridge
University of Cambridge
d'Adamo, Adamo P.
United Kingdom, Cambridge
University of Cambridge
Edwards, Todd L.
United States, Nashville
Vanderbilt University
Ellinor, Patrick T.
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
Elliott, Paul E.
United Kingdom, London
Mrc Centre for Environment and Health
Evangelou, Evangelos
United Kingdom, London
Imperial College London
Greece, Ioannina
Faculty of Medicine
Farmaki, Aliki Eleni
Greece, Athens
Harokopio University of Athens
Faul, Jessica D.
United States, Ann Arbor
University of Michigan, Ann Arbor
Feitosa, Mary Furlan
United States, St. Louis
Washington University School of Medicine in St. Louis
Ferrannini, Ele
Italy, Pisa
Istituto Di Fisiologia Clinica Del Cnr
Italy, Pisa
Università Di Pisa
Ferrario, Marco Mario
Italy, Varese
Università Degli Studi Dell'insubria
Ferrières, Jean
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Florez, Jose C.
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Ford, Ian
United Kingdom, Glasgow
University of Glasgow
Fornage, Myriam
United States, Houston
University of Texas Health Science Center at Houston
Franks, Paul W.
Sweden, Lund
Lunds Universitet
United States, Boston
Harvard T.h. Chan School of Public Health
Sweden, Umea
Umeå Universitet
Frikke- Schmidt, Ruth
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Copenhagen University Hospital
Galesloot, Tessel E.
Netherlands, Nijmegen
Radboud University Medical Center
Gan, Wei
United Kingdom, Oxford
University of Oxford
Gandin, Ilaria
Italy, Trieste
Università Degli Studi Di Trieste
Gasparini, Paolo P.
Italy, Trieste
Università Degli Studi Di Trieste
Qatar, Doha
Sidra Medicine
Giedraitis, Vilmantas
Sweden, Uppsala
Uppsala Universitet
Giri, Ayush
United States, Nashville
Vanderbilt University
Girotto, Giorgia G.
Italy, Trieste
Università Degli Studi Di Trieste
Qatar, Doha
Sidra Medicine
Gordon, Scott D.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Gordon-Larsen, Penny
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Gorski, Mathias M.
Germany, Regensburg
Universität Regensburg
Germany, Regensburg
Klinikum Der Universität Regensburg Und Medizinische Fakultät
Grarup, Niels
Denmark, Copenhagen
Københavns Universitet
Grove, Megan L.
United States, Houston
University of Texas Health Science Center at Houston
Gudnason, V. G.
Iceland, Reykjavik
Haskoli Islands
Iceland, Kopavogur
Icelandic Heart Association
Gustafsson, Stefan
Sweden, Solna
Science for Life Laboratory
Hansen, Torben Frøstrup
Denmark, Copenhagen
Københavns Universitet
Harris, Tamara B.
United States, Bethesda
National Institutes of Health Nih
Hattersley, Andrew T.
United Kingdom, Exeter
University of Exeter
Hayward, Caroline
United Kingdom, Edinburgh
The University of Edinburgh
He, Liang
United States, Durham
Duke University
Finland, Helsinki
Helsingin Yliopisto
Heid, Iris Maria
Germany, Regensburg
Universität Regensburg
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Heikkilä, Kauko V.
Finland, Helsinki
Helsingin Yliopisto
Hernesniemi, Jussi A.
Finland, Tampere
University Hospital of Tampere
Finland, Tampere
Fimlab Laboratoriot oy
Finland, Tampere
Tampere University
Hewitt, A. W.
Australia, Melbourne
Centre for Eye Research Australia
Australia, Perth
The University of Western Australia
Australia, Hobart
University of Tasmania
Hocking, Lynne J.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Aberdeen
University of Aberdeen
Hollensted, Mette
Denmark, Copenhagen
Københavns Universitet
Holmen, Oddgeir Lingaas
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Hovingh, Gerard Kees
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Howson, Joanna M.M.
United Kingdom, Cambridge
University of Cambridge
Hoyng, Carel B.
Netherlands, Nijmegen
Radboud University Medical Center
Huang, Paul Lee
United States, Boston
Massachusetts General Hospital
Hveem, Kristian
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Ikram, Mohammad Arfan
Netherlands, Rotterdam
Erasmus Mc
Ingelsson, Erik
Sweden, Solna
Science for Life Laboratory
United States, Stanford
Stanford University School of Medicine
Jackson, Anne U.
United States, Ann Arbor
University of Michigan School of Public Health
Jansson, Jan Håkan
Sweden, Umea
Umeå Universitet
Jarvik, Gail P.
United States, Seattle
University of Washington
Jhun, Mina A.
United States, Ann Arbor
University of Michigan, Ann Arbor
Jia, Yucheng
United States, Torrance
The Lundquist Institute
Johansson, Stefan E.
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Jørgensen, Marit E. Eika
Denmark, Odense
Syddansk Universitet
Denmark, Herlev
Steno Diabetes Center Copenhagen
Jörgensen, Torben J.
Denmark, Copenhagen
Københavns Universitet
Denmark, Aalborg
Aalborg University
Denmark, Glostrup
Research Centre for Prevention and Health
Jousilahti, Pekka J.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Jukema, Johan Wouter
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Amsterdam
Royal Netherlands Academy of Arts and Sciences - Knaw
Kahn, René S.
Netherlands, Utrecht
University Medical Center Utrecht
Kähönen, Mika A.P.
Finland, Tampere
Tampere University
Kanoni, Stavroula
United Kingdom, London
Queen Mary University of London
Kaprio, Jaakko A.
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Karaleftheri, Maria
Greece, Xanthi
Echinos Medical Centre
Kardia, Sharon L.R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Karpe, Fredrik
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Kee, Frank
United Kingdom, Belfast
Queen's University Belfast
Keeman, Renske
Netherlands, Amsterdam
The Netherlands Cancer Institute
Kiemeney, Lambertus A.L.M.
Netherlands, Nijmegen
Radboud University Medical Center
Kitajima, Hidetoshi
United Kingdom, Oxford
University of Oxford
Komulainen, Pirjo
Finland, Kuopio
Itä-suomen Yliopisto
Kontto, Jukka P.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Kooner, Jaspal Singh
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
United Kingdom, London
Imperial College Healthcare Nhs Trust
United Kingdom, London
Imperial College London
Kooperberg, Charles L.
United States, Seattle
Fred Hutchinson Cancer Center
Kovács, Péter F.
Germany, Leipzig
Universität Leipzig
Kriebel, Jennifer
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Kuivaniemi, Helena
United States, Danville
Weis Center for Research
South Africa, Stellenbosch
Stellenbosch University
Küry, Sébastien
France, Nantes
Chu de Nantes
Kuusisto, Johanna K.
Finland, Kuopio
Kuopio University Hospital
la Bianca, Martina
Italy, Trieste
Irccs Burlo Garofolo
Laakso, M. M.
Finland, Kuopio
Kuopio University Hospital
Lakka, Timo Antero
Finland, Kuopio
Itä-suomen Yliopisto
Lange, Ethan Mather
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lange, Leslie A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Langefeld, Carl D.
United States, Winston Salem
Wake Forest University School of Medicine
Langenberg, Claudia C.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Larson, Eric B.
United States, Seattle
University of Washington
United States, Seattle
Group Health Research Institute
United States, Washington, D.c.
United States Department of Health and Human Services
Lee, Ii Te
Taiwan, Taichung
Veterans General Hospital-taichung Taiwan
Taiwan, Taipei
National Yang-ming University Taiwan
Taiwan, Taichung
Chung Shan Medical University
Lehtimäki, Terho J.
Finland, Tampere
Fimlab Laboratoriot oy
Finland, Tampere
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Lewis, Cora Elizabeth
United States, Birmingham
Heersink School of Medicine
Li, Jin
United States, Stanford
Stanford University School of Medicine
Li-Gao, Ruifang
Netherlands, Leiden
Leids Universitair Medisch Centrum
Lin, Honghuang
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Lin, Lian
United States, Houston
University of Texas Health Science Center at Houston
Lin, Xu
China, Shanghai
Shanghai Institute of Nutrition and Health
Lind, Lars L.
Sweden, Uppsala
Uppsala Universitet
Lindstr̈om, Jaana
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Linneberg, Allan R.
Denmark, Copenhagen
Københavns Universitet
Denmark, Glostrup
Research Centre for Prevention and Health
Denmark, Copenhagen
Rigshospitalet
Liu, Yongmei
United States, Winston Salem
Wake Forest University School of Medicine
Lophatananon, Artitaya
United Kingdom, Coventry
University of Warwick
Luan, Jian'fan N.An
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Lubitz, Steven A.
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
Lyytikäinen, Leo Pekka
Finland, Tampere
Fimlab Laboratoriot oy
Finland, Tampere
Tampere University
Mackey, David A.
Australia, Perth
The University of Western Australia
Madden, Pamela A.F.
United States, St. Louis
Washington University in St. Louis
Manning, Alisa Knodle
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Männistö, Satu
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Marenne, Gaëlle
United Kingdom, Hinxton
Wellcome Sanger Institute
Marten, Jonathan
United Kingdom, Edinburgh
The University of Edinburgh
Martin, Nicholas G.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Meidtner, Karina
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Nuthetal
German Institute of Human Nutrition
Metspalu, Andres H.
Estonia, Tartu
Tartu Ülikool
Mitchell, Paul G.
Australia, Parramatta
The Westmead Institute for Medical Research
Mohlke, Karen
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Mook-Kanamori, Dennis Owen
Netherlands, Leiden
Leids Universitair Medisch Centrum
Morgan, Anna
Italy, Trieste
Università Degli Studi Di Trieste
Morris, Andrew D.
United Kingdom, Edinburgh
The University of Edinburgh
Morris, Andrew Paul
United Kingdom, Oxford
University of Oxford
United Kingdom, Liverpool
University of Liverpool
Müller-Nurasyid, Martina
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Munroe, Patricia B.
United Kingdom, London
Queen Mary University of London
Nalls, Mike A.
United States, Bethesda
National Institutes of Health Nih
Nauck, Matthias A.
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Germany, Greifswald
Universitätsmedizin Greifswald
Nelson, Christopher P.
United Kingdom, Leicester
Glenfield Hospital
Neville, Matt J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Nielsen, Sune Fallgaard
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Nikus, Kjell Christer
Finland, Tampere
Tampere University
Njolstad, Pãl Rasmus
Norway, Bergen
Haukeland Universitetssjukehus
Norway, Bergen
Universitetet I Bergen
Nordestgaard, BØrge Grønne
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Ntalla, Ioanna
United Kingdom, London
Queen Mary University of London
Oksa, Heikki H.
Finland, Tampere
University Hospital of Tampere
Olde Loohuis, Loes M.
United States, Los Angeles
University of California, Los Angeles
Ophoff, R. A.
Netherlands, Utrecht
University Medical Center Utrecht
United States, Los Angeles
University of California, Los Angeles
Owen, Katharine R.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Packard, Christopher J.D.
United Kingdom, Glasgow
University of Glasgow
Padmanabhan, Sandosh
United Kingdom, Glasgow
University of Glasgow
Palmer, Colin Neil Alexander
United Kingdom, Dundee
University of Dundee School of Medicine
Pasterkamp, Gerard G.
Netherlands, Utrecht
University Medical Center Utrecht
Pattie, Alison
United Kingdom, Edinburgh
The University of Edinburgh
Pedersen, Oluf Borbye
Denmark, Copenhagen
Københavns Universitet
Peissig, Peggy L.
United States, Marshfield
Marshfield Clinic
Peloso, Gina Marie
United States, Boston
Massachusetts General Hospital
United States, Cambridge
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Pennell, Craig Edward
Australia, Perth
The University of Western Australia
Perola, Markus
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsingin Yliopisto
Estonia, Tartu
Tartu Ülikool
Perry, John R.B.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Pirie, Ailith
United Kingdom, Cambridge
University of Cambridge
Polašek, Ozren
United Kingdom, Edinburgh
The University of Edinburgh
Croatia, Split
School of Medicine, University of Split
Posthuma, Daniëlle
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Raitakari, Olli T.
Finland, Turku
Turun Yliopistollinen Keskussairaala
Finland, Turku
Turun Yliopisto
Rasheed, Asif
Pakistan, Karachi
Centre for Non-communicable Diseases
Rauramaa, Rainer
Finland, Kuopio
Itä-suomen Yliopisto
Finland, Kuopio
Kuopio University Hospital
Reilly, Dermot F.
United States, Rahway
Merck & Co., Inc.
Reiner, Alexander Paul
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Renström, Frida
Sweden, Lund
Lunds Universitet
Sweden, Umea
Umeå Universitet
Ridker, Paul M.
United States, Boston
Harvard Medical School
Rioux, John David
Canada, Montreal
Institut de Cardiologie de Montreal
Canada, Montreal
University of Montreal
Robertson, Neil R.
United Kingdom, Oxford
University of Oxford
Robino, Antonietta
Italy, Trieste
Irccs Burlo Garofolo
Rolandsson, Olov
Sweden, Umea
Umeå Universitet
Rudan, Igor
United Kingdom, Edinburgh
The University of Edinburgh
Ruth, Katherine S.
United Kingdom, Exeter
University of Exeter
Saleheen, Danish
Pakistan, Karachi
Centre for Non-communicable Diseases
United States, Philadelphia
University of Pennsylvania
Salomaa, Veikko V.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Samani, Nilesh J.
United Kingdom, Leicester
Glenfield Hospital
Sapkota, Yadav A.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Sattar, Naveed A.
United Kingdom, Glasgow
University of Glasgow
Schmidt, Marjanka K.
Netherlands, Amsterdam
The Netherlands Cancer Institute
Schreiner, Pamela J.
United States, Minneapolis
University of Minnesota Twin Cities
Schulze, Matthias Bernd
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Nuthetal
German Institute of Human Nutrition
Scott, Robert A.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Segura-Lepe, Marcelo P.
United Kingdom, London
Imperial College London
Shah, Svati H.
United States, Durham
Duke University
Sim, Xueling
United States, Ann Arbor
University of Michigan School of Public Health
Singapore, Singapore City
National University of Singapore
Sivapalaratnam, Suthesh
United States, Boston
Massachusetts General Hospital
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
United Kingdom, Cambridge
University of Cambridge
Small, Kerrin S.
United Kingdom, London
King's College London
Smith, Albert Vernon
Iceland, Reykjavik
Haskoli Islands
Iceland, Kopavogur
Icelandic Heart Association
Smith, Jennifer A.
United States, Ann Arbor
University of Michigan, Ann Arbor
Southam, Lorraine
United Kingdom, Oxford
University of Oxford
United Kingdom, Hinxton
Wellcome Sanger Institute
Spector, Tim David
United Kingdom, London
King's College London
Speliotes, Elizabeth K.
United States, Ann Arbor
University of Michigan, Ann Arbor
Starr, John M.
United Kingdom, Edinburgh
The University of Edinburgh
Steinthórsdóttir, Valgerdur
Iceland, Reykjavik
Decode Genetics
Stringham, Heather M.
United States, Ann Arbor
University of Michigan School of Public Health
Stumvoll, Michael W.
Germany, Leipzig
Universität Leipzig
Surendran, Praveen
United Kingdom, Cambridge
University of Cambridge
Tansey, Katherine E.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Cardiff
Cardiff University
Tardif, Jean Claude
Canada, Montreal
Institut de Cardiologie de Montreal
Canada, Montreal
University of Montreal
Taylor, Kent D.
United States, Torrance
The Lundquist Institute
Teumer, Alexander
Germany, Greifswald
Universitätsmedizin Greifswald
Thompson, Deborah J.
United Kingdom, Cambridge
University of Cambridge
Thorsteinsdóttir, Unnur Arna
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Thuesen, Betina Heinsbæk
Denmark, Glostrup
Research Centre for Prevention and Health
Tönjes, Anke
Germany, Leipzig
Universität Leipzig
Tromp, Gerard C.
United States, Danville
Weis Center for Research
South Africa, Stellenbosch
Stellenbosch University
Trompet, Stella
Netherlands, Leiden
Leids Universitair Medisch Centrum
Tsafantakis, Emmanouil
Unknown Affiliation
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Austria, Krems an Der Donau
Donau-universität Krems
Kuwait, Dasman
Dasman Diabetes Institute
Saudi Arabia, Jeddah
King Abdulaziz University
Tybjaerg-Hansen, Anne
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Copenhagen University Hospital
Tyrer, Jonathan P.
United Kingdom, Cambridge
University of Cambridge
Uher, Rudolf
Canada, Halifax
Dalhousie University, Faculty of Medicine
Uitterlinden, André G.
Netherlands, Rotterdam
Erasmus Mc
Ulivi, Sheila
Italy, Trieste
Irccs Burlo Garofolo
van der Laan, Sander W.
Netherlands, Utrecht
University Medical Center Utrecht
van Duijn, Cornelia M.
Netherlands, Rotterdam
Erasmus Mc
van Schoor, Natasja M.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
van Setten, Jessica A.
Netherlands, Utrecht
University Medical Center Utrecht
Varbo, Anette
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Varga, Tibor V.
Sweden, Lund
Lunds Universitet
Varma, Rohit
United States, Los Angeles
University of Southern California
Edwards, Digna R.Velez
United States, Nashville
Vanderbilt University
Vermeulen, Sita H.H.M.
Netherlands, Nijmegen
Radboud University Medical Center
Vitart, Véronique
United Kingdom, Edinburgh
The University of Edinburgh
Vogt, Thomas Francis
United States, Rahway
Merck & Co., Inc.
Walker, Mark A.
United Kingdom, Newcastle
Newcastle University
Wang, Carol A.
Australia, Perth
The University of Western Australia
Wang, Shuai
United States, Boston
School of Public Health
Wareham, Nicholas J.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Warren, Helen R.
United Kingdom, London
Queen Mary University of London
Wessel, Jennifer
United States, Bloomington
Indiana University Bloomington
Willems, Sara M.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Wilson, James Gaines
United States, Jackson
University of Mississippi Medical Center
Witte, Daniel R.
Denmark, Odense
Danish Diabetes Academy
Denmark, Aarhus
Aarhus Universitet
Woods, Michael O.
Canada, St John's
Memorial University of Newfoundland
Wu, Ying
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Yaghootkar, Hanieh
United Kingdom, Exeter
University of Exeter
Yao, Jie
United States, Torrance
The Lundquist Institute
Yerges-Armstrong, Laura M.
United States, Baltimore
University of Maryland School of Medicine
United States, Philadelphia
Glaxosmithkline, Usa
Young, Robin D.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Glasgow
University of Glasgow
Zeggini, Eleftheria
United Kingdom, Hinxton
Wellcome Sanger Institute
Zhan, Xiaowei
United States, Dallas
Ut Southwestern Medical Center
Zhang, Weihua
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
United Kingdom, London
Imperial College London
Zhao, Jinghua
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Zhao, Wei
United States, Ann Arbor
University of Michigan, Ann Arbor
United States, Philadelphia
University of Pennsylvania
Rotter, Jerome I.
United States, Torrance
The Lundquist Institute
Boehnke, Michael L.
United States, Ann Arbor
University of Michigan School of Public Health
Kathiresan, Sekar
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
McCarthy, Mark I.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Willer, Cristen J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Stefánsson, Kari
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Borecki, Ingrid B.
United States, St. Louis
Washington University School of Medicine in St. Louis
Liu, Dajiang J.
United States, Hershey
Penn State College of Medicine
North, Kari E.
Unknown Affiliation
Heard-Costa, Nancy L.
United States, Framingham
Framingham Heart Study
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Pers, Tune H.
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Statens Serum Institut
Lindgren, Cecilia M.
United Kingdom, Oxford
University of Oxford
Oxvig, Claus
Denmark, Aarhus
Aarhus Universitet
Kutalik, Zoltán
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Rivadeneira, Fernando F.
Netherlands, Rotterdam
Erasmus Mc
Loos, Ruth J.F.
United States, New York
Icahn School of Medicine at Mount Sinai
Frayling, Tim M.
United Kingdom, Exeter
University of Exeter
Hirschhorn, Joel N.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Deloukas, Panos
United Kingdom, London
Queen Mary University of London
Saudi Arabia, Jeddah
King Abdulaziz University
Lettre, Guillaume
Canada, Montreal
Institut de Cardiologie de Montreal
Canada, Montreal
University of Montreal
Statistics
Citations: 399
Authors: 340
Affiliations: 170
Identifiers
Doi:
10.1038/nature21039
ISSN:
00280836
Research Areas
Genetics And Genomics
Study Design
Cohort Study