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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix
British Journal of Cancer, Volume 44, No. 2, Year 1981
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Description
Nuclear and cytoplasmic oestrogen receptors (REN and REC) were sought in 5 normal cervices and in 43 specimens of squamous carcinoma of the cervix. All 3 tissues components of the 5 normal cervices contained both REN and REC. Thirty-five (81%) of the tumours contained receptors, but in only 9 (21%) were they found in both subcellular compartments. Twenty-four tumours (56%) had only REC and 2 had only REN. The potential therapeutic significance of these findings is not yet known, but it seems possible that tumours with an intact receptor mechanism might benefit from oestrogen therapy and have a more favourable prognosis. © 1981, Cancer Research Campaign. All rights reserved.
Authors & Co-Authors
Soutter, William Patrick
South Africa, Durban
University of Kwazulu-natal
United Kingdom, Sheffield
The University of Sheffield
Pegoraro, Rosemary J.
Unknown Affiliation
Green-Thompson, Ronald W.
Unknown Affiliation
Naidoo, D.
South Africa, Durban
University of Kwazulu-natal
Joubert, Septimus M.
Unknown Affiliation
Philpott, R. Hugh
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 25
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1038/bjc.1981.165
e-ISSN:
15321827
Research Areas
Cancer