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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity
Immunity, Volume 54, No. 5, Year 2021
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Description
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine unmanipulated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells. By using peptide-human leukocyte antigen (HLA) tetramers for direct ex vivo analysis, we characterized CD8+ T cells specific for SARS-CoV-2 epitopes in COVID-19 patients and unexposed individuals. Unlike CD8+ T cells directed toward subdominant epitopes (B7/N257, A2/S269, and A24/S1,208) CD8+ T cells specific for the immunodominant B7/N105 epitope were detected at high frequencies in pre-pandemic samples and at increased frequencies during acute COVID-19 and convalescence. SARS-CoV-2-specific CD8+ T cells in pre-pandemic samples from children, adults, and elderly individuals predominantly displayed a naive phenotype, indicating a lack of previous cross-reactive exposures. T cell receptor (TCR) analyses revealed diverse TCRαβ repertoires and promiscuous αβ-TCR pairing within B7/N105+CD8+ T cells. Our study demonstrates high naive precursor frequency and TCRαβ diversity within immunodominant B7/N105-specific CD8+ T cells and provides insight into SARS-CoV-2-specific T cell origins and subsequent responses. © 2021 Elsevier Inc.
Authors & Co-Authors
Nguyen, Thi H.O.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Juno, Jennifer A.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Amanat, Fatima
United States, New York
Icahn School of Medicine at Mount Sinai
Krammer, Florian H.
United States, New York
Icahn School of Medicine at Mount Sinai
Doolan, Denise L.
Australia, Townsville
James Cook University
Flanagan, Katie L.
Australia, Hobart
University of Tasmania
Australia, Clayton
Monash University
Australia, Melbourne
Rmit University
Australia, Launceston
Launceston General Hospital
Mouhtouris, Effie
Australia, Melbourne
Austin Hospital
Trubiano, Jason Anthony
Australia, Melbourne
Peter Maccallum Cancer Centre
Australia, Melbourne
Austin Health
Cheng, Allen C.
Australia, Melbourne
Alfred Health
Australia, Clayton
Monash University
Thomas, Paul G.
United States, Memphis
St. Jude Children's Research Hospital
Wheatley, Adam Kenneth
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Australia, Melbourne
University of Melbourne
Kent, Stephen J.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Australia, Melbourne
University of Melbourne
Australia, Clayton
Monash University
Rossjohn, Jamie
Australia, Clayton
Monash University
United Kingdom, Cardiff
Cardiff University School of Medicine
Torresi, Joseph
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Kedzierska, Katherine
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Japan, Sapporo
Hokkaido University
Statistics
Citations: 79
Authors: 15
Affiliations: 17
Identifiers
Doi:
10.1016/j.immuni.2021.04.009
ISSN:
10747613
Research Areas
Covid
Maternal And Child Health