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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
An investigation of a major outbreak of rift valley fever in Kenya: 2006-2007
American Journal of Tropical Medicine and Hygiene, Volume 83, No. 2 SUPPL., Year 2010
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Description
An outbreak of Rift Valley fever (RVF) occurred in Kenya during November 2006 through March 2007. We characterized the magnitude of the outbreak through disease surveillance and serosurveys, and investigated contributing factors to enhance strategies for forecasting to prevent or minimize the impact of future outbreaks. Of 700 suspected cases, 392 met probable or confirmed case definitions; demographic data were available for 340 (87%), including 90 (26.4%) deaths. Male cases were more likely to die than females, Case Fatality Rate Ratio 1.8 (95% Confidence Interval [CI] 1.3-3.8). Serosurveys suggested an attack rate up to 13% of residents in heavily affected areas. Genetic sequencing showed high homology among viruses from this and earlier RVF outbreaks. Case areas were more likely than non-case areas to have soil types that retain surface moisture. The outbreak had a devastatingly high case-fatality rate for hospitalized patients. However, there were up to 180,000 infected mildly ill or asymptomatic people within highly affected areas. Soil type data may add specificity to climate-based forecasting models for RVF. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Nguku, Patrick Mboya
Kenya, Nairobi
Ministry of Public Health and Sanitation
Sharif, Shahnaaz K.
Kenya, Nairobi
Ministry of Public Health and Sanitation
Mutonga, David M.
Kenya, Nairobi
Ministry of Health Nairobi
Amwayi, Samuel Anyangu
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Omolo, Jared Odhiambo
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Mohammed, Omar
Unknown Affiliation
Farnon, Eileen C.
United States, Atlanta
Centers for Disease Control and Prevention
Gould, L. Hannah
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Lederman, Edith R.
United States, San Diego
Naval Medical Center San Diego
Rao, C. Y.
United States, Atlanta
Centers for Disease Control and Prevention
Sang, Rosemary C.
Kenya, Nairobi
Kenya Medical Research Institute
Schnabel, David C.
Kenya
Us Army Medical Research Unit
Feikin, Daniel R.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Hightower, Allen W.
United States, Atlanta
Centers for Disease Control and Prevention
Njenga, Moses Kariuki
Kenya, Nairobi
International Emerging Infections Program
Breiman, Robert F.
Kenya, Nairobi
Office of the Director
Statistics
Citations: 183
Authors: 16
Affiliations: 11
Identifiers
Doi:
10.4269/ajtmh.2010.09-0288
ISSN:
00029637
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Locations
Kenya
Participants Gender
Male
Female