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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The association between the estimated glomerular filtration rate and cognitive impairment: the Suita Study
Hypertension Research, Year 2023
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Description
This cross-sectional study investigated the association between the estimated glomerular filtration rate (eGFR), a measure of chronic kidney disease (CKD), and cognitive impairment. We used data from 6215 Japanese individuals registered in the Suita Study. Cognitive impairment was defined as a Mini-Mental State Examination (MMSE) score of ≤ 26. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) of cognitive impairment for eGFR 45–59.9 and < 45 mL/min/1.73 m2 (mild and moderate-to-severe eGFR reductions) compared to eGFR ≥ 60 mL/min/1.73 m2 (normal eGFR). The results showed that both mild and moderate-to-severe eGFR reductions were associated with cognitive impairment: ORs (95% CIs) = 1.49 (1.22–1.83) and 2.35 (1.69–3.26), respectively (p-trend < 0.001). Each increment of eGFR by 10 mL/min/1.73m2 was associated with 4.8% lower odds of cognitive impairment. In conclusion, eGFR reduction was associated with cognitive impairment. Managing CKD is essential for preventing cognitive impairment. [Figure not available: see fulltext.]. © 2023, The Author(s), under exclusive licence to The Japanese Society of Hypertension.
Authors & Co-Authors
Arafa, Ahmed Emadeldin
Japan, Suita
National Cerebral and Cardiovascular Center
Egypt, Beni Suef
Beni-suef University
Kawachi, Haruna
Japan, Suita
National Cerebral and Cardiovascular Center
Japan, Suita
Osaka University
Matsumoto, Chisa
Japan, Suita
National Cerebral and Cardiovascular Center
Japan, Tokyo
Tokyo Medical University Hospital
Teramoto, Masayuki
Japan, Suita
National Cerebral and Cardiovascular Center
Matsuo, Miki
Japan, Suita
National Cerebral and Cardiovascular Center
Nakao, Yoko M.
Japan, Suita
National Cerebral and Cardiovascular Center
Japan, Kyoto
Kyoto University
Kashima, Rena
Japan, Suita
National Cerebral and Cardiovascular Center
Kokubo, Yoshihiro
Japan, Suita
National Cerebral and Cardiovascular Center
Statistics
Citations: 2
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1038/s41440-023-01476-8
ISSN:
09169636
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative