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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Biochemical markers of nutritional status and childhood malaria severity in Cameroon
British Journal of Nutrition, Volume 104, No. 6, Year 2010
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Description
To investigate the part played by undernutrition in malaria severity, some biomarkers of nutritional status were assessed in children with severe malarial anaemia (MA) and cerebral malaria (CM) in comparison with healthy children or those with uncomplicated malaria. Undernutrition was assessed using the weight-for-age Z score (WAZ). Retinol was determined by HPLC; lipid profile, Ca, Mg and albumin were determined by spectrophotometry. Severe and moderate undernutritions were more prevalent in children with MA and those with the combined symptoms of CM and MA, but not in those with CM alone. Some perturbations were noticed in the lipid profile, but most of the values remained within the normal ranges. The risk of vitamin A deficiency, as assessed by plasma retinol concentration, was noteworthy in children with severe malaria: 048106 and 050106mol/l, respectively, in children with MA and CM (reference value: >07106mol/l). A significant difference was obtained for retinol values after an ANOVA of all the groups (P=00029), with the value in the MA group being significantly low than that in the control group (P<005); likewise, a significant difference was obtained after comparison of all the groups for Mg and albumin (P=00064 and 00082, respectively). Despite their low number (n 6), fatal cases of CM had a normal mean WAZ on admission, but low values of retinol, albumin and HDL:LDL ratio. Despite these associations, undernutrition itself did not appear to be a primary factor associated with fatal outcome. Copyright © The Authors 2010.
Authors & Co-Authors
Pankoui Mfonkeu, Joël Bertrand
Cameroon, Douala
University of Douala
Gouado, Inocent
Cameroon, Douala
University of Douala
Fotso Kuaté, Honoré
Cameroon, Douala
Hôpital Laquintinie
Zambou, Odile
Cameroon, Douala
Deido District Hospital
Combes, Valery
Australia, Sydney
Faculty of Medicine and Health
Grau, Georges Emile Raymond
Australia, Sydney
Faculty of Medicine and Health
Amvam-Zollo, Paul Henri
Cameroon, Douala
University of Douala
Statistics
Citations: 22
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1017/S0007114510001510
ISSN:
00071145
e-ISSN:
14752662
Research Areas
Food Security
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Study Locations
Cameroon