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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy
Journal of Infectious Diseases, Volume 197, No. 2, Year 2008
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Description
Background. Leprosy is characterized by a spectrum of clinical manifestations that depend on the type of immune response against the pathogen. Patients may undergo immunological changes known as "reactional states" (reversal reaction and erythema nodosum leprosum) that result in major clinical deterioration. The goal of the present study was to assess the effect of Toll-like receptor 2 (TLR2) polymorphisms on susceptibility to and clinical presentation of leprosy. Methods. Three polymorphisms in TLR2 (597C→T, 1350T→C, and a microsatellite marker) were analyzed in 431 Ethiopian patients with leprosy and 187 control subjects. The polymorphism-associated risk of developing leprosy, lepromatous (vs. tuberculoid) leprosy, and leprosy reactions was assessed by multivariate logistic regression models. Results. The microsatellite and the 597C→T polymorphisms both influenced susceptibility to reversal reaction. Although the 597T allele had a protective effect (odds ratio [OR], 0.34 [95% confidence interval {CI}, 0.17- 0.68]; P = .002 under the dominant model), homozygosity for the 280-bp allelic length of the microsatellite strongly increased the risk of reversal reaction (OR, 5.83 [95% CI, 1.98 -17.15]; P = .001 under the recessive model). These associations were consistent among 3 different ethnic groups. Conclusions. These data suggest a significant role for TLR-2 in the occurrence of leprosy reversal reaction and provide new insights into the immunogenetics of the disease. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Bochud, Pierre Yves
United States, Seattle
University of Washington
United States, Seattle
Institute for Systems Biology
Hawn, Thomas Richard
United States, Seattle
University of Washington
Siddiqui, Mahveen Ruby
United States, Newark
Public Health Research Institute
United Kingdom, London
Public Health England
Saunderson, Paul R.
Ethiopia, Addis Ababa
All Africa Leprosy, Tuberculosis and Rehabilitation Training Centre Addis Ababa
United States, Greenville
American Leprosy Missions
Britton, Sven F.F.
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Sweden, Stockholm
Karolinska Institutet
Abraham, Isaac
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Argaw, Azeb Tadesse
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
United States, New York
Icahn School of Medicine at Mount Sinai
Janer, Marta
United States, Seattle
University of Washington
Zhao, Lueping
United States, Seattle
Fred Hutchinson Cancer Research Center
Kaplan, Gilla
United States, Newark
Public Health Research Institute
Aderem, Alan A.
United States, Seattle
University of Washington
Statistics
Citations: 136
Authors: 11
Affiliations: 10
Identifiers
Doi:
10.1086/524688
ISSN:
00221899
Research Areas
Genetics And Genomics
Study Design
Case-Control Study