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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Capsaicin pretreatment attenuates LPS-induced hypothermia through TRPV1-independent mechanisms in chicken
Life Sciences, Volume 82, No. 23-24, Year 2008
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Description
It has been demonstrated that chicken TRPV1 (transient receptor potential vanilloid of subtype-1) is insensitive to capsaicin (CAP), and therefore, a chicken model is suitable to analyze the CAP-sensitive TRPV1-independent pathway. We elucidated here the possible involvement of the pathway in hypothermia induced by bacterial endotoxin (lipopolysaccharide, LPS) in chickens. Chicks were pretreated with CAP (10 mg/kg, iv) at 1, 2 and 3 days of age to desensitize them towards the CAP-sensitive pathway. An intravenous injection of LPS in 4-day-old chicks caused progressive hypothermia, ending with collapse and 78% mortality within 12 h after injection. The CAP pretreatment rescued the LPS-induced endotoxin shock and hypothermia in chicks. LPS-induced iNOS expression as well as NO production in liver and lung was suppressed by CAP pretreatment. CAP pretreatment also attenuated hypothermia due to exposure of chicks to cold ambient temperature. These findings suggest that a CAP-sensitive TRPV1-independent pathway may be involved in pathophysiological hypothermic reactions through the mediation of NO in chickens. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Nikami, Hideki
Japan, Gifu
United Graduate School of Veterinary Sciences, Gifu University
Japan, Gifu
Gifu University
Mahmoud, Motamed Elsayed
Japan, Gifu
United Graduate School of Veterinary Sciences, Gifu University
Egypt
Animal Behavior
Shimizu, Yasutake
Japan, Gifu
United Graduate School of Veterinary Sciences, Gifu University
Shiina, Takahiko
Japan, Gifu
United Graduate School of Veterinary Sciences, Gifu University
Hirayama, Haruko
Japan, Gifu
United Graduate School of Veterinary Sciences, Gifu University
Iwami, Momoe
Japan, Gifu
United Graduate School of Veterinary Sciences, Gifu University
Dosoky, R. M.
Egypt
Animal Behavior
Ahmed, Moustafa Mohamed
Egypt
Animal Behavior
Takewaki, Tadashi
Japan, Gifu
United Graduate School of Veterinary Sciences, Gifu University
Statistics
Citations: 25
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.lfs.2008.04.003
ISSN:
00243205