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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Serum long-chain n-3 polyunsaturated fatty acids, methylmercury and blood pressure in an older population
Hypertension Research, Volume 35, No. 10, Year 2012
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Description
Fish or fish oil consumption has been associated with lower blood pressure. Fish may also contain methylmercury, which has been associated with cardiovascular diseases and higher blood pressure. Our aim was to study the associations of serum long-chain n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), mainly reflecting fish or fish oil intake, and hair mercury concentration with blood pressure. Data were available for 848 men and 909 women from the Kuopio Ischaemic Heart Disease Risk Factor Study, aged 53-73 years. We excluded participants with ischemic heart disease, stroke, diabetes or hypertension treatment, leaving 396 men and 372 women. Log-transformed values were used to study the associations. The mean serum concentrations were 1.63% (s.d. 0.91) for EPA, 0.77% (s.d. 0.16) for DPA and 2.73% (s.d. 0.90) for DHA of all serum fatty acids. Multivariate-adjusted serum EPADPADHA was associated with lower systolic blood pressure (β4.50, 95% confidence interval (CI) 8.02-0.99) and pulse pressure (β4.41, 95% CI 6.95-1.87), but not with diastolic blood pressure (β0.45, 95% CI 2.31-1.52). The associations were similar with EPA, DPA and DHA evaluated individually. The mean hair mercury concentration was 1.42 μg g 1 (s.d. 1.54). Hair mercury was not associated with blood pressure and it did not modify the association between PUFA and blood pressure. These results suggest that higher serum long-chain n-3 PUFA concentration has a modest inverse association with blood pressure in older men and women. © 2012 The Japanese Society of Hypertension All rights reserved.
Authors & Co-Authors
Virtanen, Jyrki K.
Finland, Kuopio
Itä-suomen Yliopisto
Nyantika, Asenath N.
Finland, Kuopio
Itä-suomen Yliopisto
Kenya, Eldoret
The University of Eastern Africa, Baraton
Kauhanen, Jussi
Finland, Kuopio
Itä-suomen Yliopisto
Voutilainen, Sari
Finland, Kuopio
Itä-suomen Yliopisto
Tuomainen, Tomi Pekka
Finland, Kuopio
Itä-suomen Yliopisto
Statistics
Citations: 27
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1038/hr.2012.80
ISSN:
09169636
e-ISSN:
13484214
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Male
Female