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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Using next generation sequencing to identify yellow fever virus in Uganda
Virology, Volume 422, No. 1, Year 2012
Notification
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Description
In October and November 2010, hospitals in northern Uganda reported patients with suspected hemorrhagic fevers. Initial tests for Ebola viruses, Marburg virus, Rift Valley fever virus, and Crimean Congo hemorrhagic fever virus were negative. Unbiased PCR amplification of total RNA extracted directly from patient sera and next generation sequencing resulted in detection of yellow fever virus and generation of 98% of the virus genome sequence. This finding demonstrated the utility of next generation sequencing and a metagenomic approach to identify an etiological agent and direct the response to a disease outbreak. © 2011.
Authors & Co-Authors
McMullan, Laura K.
United States, Atlanta
Centers for Disease Control and Prevention
Frace, Michael A.
United States, Atlanta
Centers for Disease Control and Prevention
Sammons, Scott A.
United States, Atlanta
Centers for Disease Control and Prevention
Shoemaker, Trevor R.
United States, Atlanta
Centers for Disease Control and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Balinandi, Stephen Karabyo
United States, Atlanta
Centers for Disease Control and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Wamala, Joseph Francis
Uganda, Kampala
Uganda Ministry of Health
Lutwama, Julius Julian
Uganda, Entebbe
Uganda Virus Research Institute
Downing, Robert G.
United States, Atlanta
Centers for Disease Control and Prevention
Ströher, Ute
United States, Atlanta
Centers for Disease Control and Prevention
MacNeil, Adam P.
United States, Atlanta
Centers for Disease Control and Prevention
Nichol, Stuart T.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 54
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1016/j.virol.2011.08.024
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Congo
Uganda