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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Systems serology detects functionally distinct coronavirus antibody features in children and elderly
Nature Communications, Volume 12, No. 1, Article 2037, Year 2021
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Description
The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses, induced by circulating human coronaviruses (hCoVs), is needed to understand such divergent clinical outcomes. Here we show analysis of coronavirus antibody responses of pre-pandemic healthy children (n = 89), adults (n = 98), elderly (n = 57), and COVID-19 patients (n = 50) by systems serology. Moderate levels of cross-reactive, but non-neutralizing, SARS-CoV-2 antibodies are detected in pre-pandemic healthy individuals. SARS-CoV-2 antigen-specific Fcγ receptor binding accurately distinguishes COVID-19 patients from healthy individuals, suggesting that SARS-CoV-2 infection induces qualitative changes to antibody Fc, enhancing Fcγ receptor engagement. Higher cross-reactive SARS-CoV-2 IgA and IgG are observed in healthy elderly, while healthy children display elevated SARS-CoV-2 IgM, suggesting that children have fewer hCoV exposures, resulting in less-experienced but more polyreactive humoral immunity. Age-dependent analysis of COVID-19 patients, confirms elevated class-switched antibodies in elderly, while children have stronger Fc responses which we demonstrate are functionally different. These insights will inform COVID-19 vaccination strategies, improved serological diagnostics and therapeutics. © 2021, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8016934/bin/41467_2021_22236_MOESM1_ESM.pdf
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Authors & Co-Authors
Nguyen, Thi H.O.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Koutsakos, Marios
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Flanagan, Katie L.
Australia, Launceston
Launceston General Hospital
Australia, Hobart
University of Tasmania
Australia, Clayton
Monash University
Australia, Melbourne
Rmit University
Crawford, Nigel W.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Cheng, Allen C.
Australia, Clayton
Monash University
Australia, Melbourne
Alfred Health
Doolan, Denise L.
Australia, Townsville
James Cook University
Amanat, Fatima
United States, New York
Icahn School of Medicine at Mount Sinai
Krammer, Florian H.
United States, New York
Icahn School of Medicine at Mount Sinai
Watterson, Daniel
Australia, Brisbane
The University of Queensland
Young, Paul R.
Australia, Brisbane
The University of Queensland
Wines, Bruce D.
Australia, Melbourne
Burnet Institute
Australia, Melbourne
University of Melbourne
Australia, Clayton
Monash University
Hogarth, Phillip Mark
Australia, Melbourne
Burnet Institute
Australia, Melbourne
University of Melbourne
Australia, Clayton
Monash University
Juno, Jennifer A.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Wheatley, Adam Kenneth
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Australia, Melbourne
University of Melbourne
Kent, Stephen J.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Australia, Melbourne
University of Melbourne
Australia, Clayton
Monash University
Arnold, Kelly B.
United States, Ann Arbor
University of Michigan, Ann Arbor
Kedzierska, Katherine
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Chung, Amy W.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Statistics
Citations: 84
Authors: 18
Affiliations: 15
Identifiers
Doi:
10.1038/s41467-021-22236-7
ISSN:
20411723
Research Areas
Covid
Maternal And Child Health
Study Approach
Qualitative