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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Proinflammatory effects and oxidative stress within human bronchial epithelial cells exposed to atmospheric particulate matter (PM
2.5
and PM
>2.5
) collected from Cotonou, Benin
Environmental Pollution, Volume 185, Year 2014
Notification
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Description
After particulate matter (PM) collection in Cotonou (Benin), a complete physicochemical characterization of PM2.5 and PM>2.5 was led. Then, their adverse health effects were evaluated by using in vitro culture of human lung cells. BEAS-2B (bronchial epithelial cells) were intoxicated during short-term exposure at increasing PM concentrations (1.5-96 μg/cm2) to determine global cytotoxicity. Hence, cells were exposed to 3 and 12 μg/cm2 to investigate the potential biological imbalance generated by PM toxicity. Our findings showed the ability of both PM to induce oxidative stress and to cause inflammatory cytokines/chemokines gene expression and secretion. Furthermore, PM were able to induce gene expression of enzymes involved in the xenobiotic metabolism pathway. Strong correlations between gene expression of metabolizing enzymes, proinflammatory responses and cell cycle alteration were found, as well as between proinflammatory responses and cell viability. Stress oxidant parameters were highly correlated with expression and protein secretion of inflammatory mediators. © 2013 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Cachon, Boris Fresnel
France, Lille
Université de Lille
France, Dunkerque
Unité de Chimie Environnementale et Interactions Sur le Vivant
Benin, Cotonou
University of Abomey-calavi
Firmin, Stephane
France, Dunkerque
Unité de Chimie Environnementale et Interactions Sur le Vivant
France, Beauvais
Institut Polytechnique Lasalle Beauvais
Verdin, Anthony
France, Dunkerque
Unité de Chimie Environnementale et Interactions Sur le Vivant
Ayi-Fanou, Lucie
Benin, Cotonou
University of Abomey-calavi
Billet, Sylvain
France, Lille
Université de Lille
France, Dunkerque
Unité de Chimie Environnementale et Interactions Sur le Vivant
Cazier, Fabrice
France, Lille
Université de Lille
France, Dunkerque
Université du Littoral Côte D‘opale
Martin, Perrine
France, Lille
Université de Lille
France, Dunkerque
Unité de Chimie Environnementale et Interactions Sur le Vivant
Aïssi, Faustin C.
France, Lille
Université de Lille
Courcot, Dominique
France, Lille
Université de Lille
France, Dunkerque
Unité de Chimie Environnementale et Interactions Sur le Vivant
Sanni, Ambaliou
Benin, Cotonou
University of Abomey-calavi
Shirali, Pirouz
France, Lille
Université de Lille
France, Dunkerque
Unité de Chimie Environnementale et Interactions Sur le Vivant
Statistics
Citations: 146
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1016/j.envpol.2013.10.026
ISSN:
02697491
e-ISSN:
18736424
Research Areas
Genetics And Genomics
Study Locations
Benin