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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Secondary Bacterial Infections of Buruli Ulcer Lesions Before and After Chemotherapy with Streptomycin and Rifampicin
PLoS Neglected Tropical Diseases, Volume 7, No. 5, Article e2191, Year 2013
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Description
Buruli ulcer (BU), caused by Mycobacterium ulcerans is a chronic necrotizing skin disease. It usually starts with a subcutaneous nodule or plaque containing large clusters of extracellular acid-fast bacilli. Surrounding tissue is destroyed by the cytotoxic macrolide toxin mycolactone produced by microcolonies of M. ulcerans. Skin covering the destroyed subcutaneous fat and soft tissue may eventually break down leading to the formation of large ulcers that progress, if untreated, over months and years. Here we have analyzed the bacterial flora of BU lesions of three different groups of patients before, during and after daily treatment with streptomycin and rifampicin for eight weeks (SR8) and determined drug resistance of the bacteria isolated from the lesions. Before SR8 treatment, more than 60% of the examined BU lesions were infected with other bacteria, with Staphylococcus aureus and Pseudomonas aeruginosa being the most prominent ones. During treatment, 65% of all lesions were still infected, mainly with P. aeruginosa. After completion of SR8 treatment, still more than 75% of lesions clinically suspected to be infected were microbiologically confirmed as infected, mainly with P. aeruginosa or Proteus miriabilis. Drug susceptibility tests revealed especially for S. aureus a high frequency of resistance to the first line drugs used in Ghana. Our results show that secondary infection of BU lesions is common. This could lead to delayed healing and should therefore be further investigated. © 2013 Yeboah-Manu et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3642065/bin/pntd.0002191.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3642065/bin/pntd.0002191.s002.doc
Authors & Co-Authors
Yeboah-Manu, Dorothy
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Kpeli, Grace Semabia
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ruf, Marie Thérèse
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Asan-Ampah, Kobina
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Quenin-Fosu, Kwabena
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Owusu-Mireku, Evelyn
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Paintsil, Albert B.
Ghana, Accra
Korle bu Teaching Hospital
Lamptey, Isaac
Ghana, Accra
Ghana Health Service
Anku, Benjamin
Ghana, Accra
Ghana Health Service
Kwakye-Maclean, Cynthia
Ghana, Accra
Ghana Health Service
Newman, Mercy Jemima
Ghana, Accra
University of Ghana
Pluschke, Gerd
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Statistics
Citations: 54
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pntd.0002191
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Cancer
Study Locations
Ghana