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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)
American Journal of Obstetrics and Gynecology, Volume 203, No. 4, Year 2010
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Description
Objective: We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM). Study Design: A case-control study was conducted in patients with pPROM (225 mothers and 155 fetuses) and 599 mothers and 628 fetuses with a normal pregnancy; 190 candidate genes and 775 SNPs were studied. Single locus/haplotype association analyses were performed; false discovery rate was used to correct for multiple testing (q (*) = 0.15). Results: First, a SNP in tissue inhibitor of metalloproteinase 2 in mothers was significantly associated with pPROM (odds ratio, 2.12; 95% confidence interval, 1.473.07; P = .000068), and this association remained significant after correction for multiple comparisons. Second, haplotypes for Alpha 3 type IV collagen isoform precursor in the mother were associated with pPROM (global P = .003). Third, multilocus analysis identified a 3-locus model, which included maternal SNPs in collagen type I alpha 2, defensin alpha 5 gene, and endothelin 1. Conclusion: DNA variants in a maternal gene involved in extracellular matrix metabolism doubled the risk of pPROM. © 2010 Mosby, Inc. All rights reserved.
Authors & Co-Authors
Romero, Roberto J.
United States, Bethesda
National Institute of Child Health and Human Development Nichd
United States, Detroit
Wayne State University
Edwards, Digna R.Velez
United States, Nashville
Vanderbilt University
Hassan, Sonia S.
United States, Bethesda
National Institute of Child Health and Human Development Nichd
United States, Detroit
Wayne State University
Erez, Offer
United States, Bethesda
National Institute of Child Health and Human Development Nichd
United States, Detroit
Wayne State University
Chaiworapongsa, Tinnakorn
United States, Bethesda
National Institute of Child Health and Human Development Nichd
United States, Detroit
Wayne State University
Bartlett, Jacquelaine
United States, Nashville
Vanderbilt University
Salisbury, Benjamin A.
Unknown Affiliation
Oyarzun, Enrique
Chile, Santiago
Pontificia Universidad Católica de Chile
Tromp, Gerard C.
United States, Detroit
Wayne State University
Williams, Scott M.
United States, Nashville
Vanderbilt University
Menon, Ramkumar
United States, Atlanta
Emory University
Statistics
Citations: 77
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.ajog.2010.05.026
ISSN:
00029378
Research Areas
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Case-Control Study