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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Bilateral adrenal infarction, hypoadrenalism and splinter haemorrhages in the 'primary' antiphospholipid syndrome
Rheumatology, Volume 31, No. 2, Year 1992
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Description
We describe a patient with a 3-year history of recurrent deep vein thromboses (DVT) of the lower limbs, who developed adrenal insufficiency following withdrawal of warfarin therapy. Multiple splinter haemorrhages of the nail beds were evident, simultaneous with the development of adrenal infarction in the absence of infective endocarditis. CT scans of the adrenal glands were consistent with bilateral adrenal infarctions. The patient had persistently high titres of IgG anticardiolipin antibodies (aCL) over the previous 4 years in the absence of antinuclear antibodies (ANA), antibodies to double stranded deoxyribonucleic acid (dsDNA) or extractable nuclear antigens (ENA). Thrombocytopenia and an intermittently positive Coombs' test had been noted. Previous episodes of DVT were associated with inadequate warfarin control and a period of warfarin resistance. He conforms to a diagnosis of a primary antiphospholipid syndrome. © 1992 Oxford University Press.
Authors & Co-Authors
Asherson, Ronald A.
United Kingdom, London
St Thomas' Hospital
Hughes, Graham R.V.
United Kingdom, London
St Thomas' Hospital
Statistics
Citations: 45
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1093/rheumatology/31.2.117
ISSN:
14620324
Research Areas
Cancer
Health System And Policy