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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Chloroquine resistant plasmodium falciparum in indigenous residents of cameroon
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 83, No. 3, Year 1989
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Description
Thirty-nine percent (36 of 92) of children in Limbe, Cameroon, treated with chloroquine (10 mg/kg body weight on days 1 and 2, and 5 mg/kg on day 3) for falciparum malaria failed to respond within 7 d of treatment. Twenty-two of these children with chloroquine-resistant malaria were successfully treated with Fansidar [one-half tablet (250 mg sulfadoxine and 25 mg pyrimethamine) per 10 kg body weight], while the other 14 children were cured with mefloquine (25 mg/kg body weight). In vitro, a combination of verapamil at 10x10 M with chloroquine or desethylchloroquine reversed resistance to the antimalarial drug and its primary metabolite in each of the 2 isolates successfully adapted and maintained in continuous culture. Similar combinations had no effect on susceptibilities of a sensitive reference clone, D6, used as control. Both chloroquine-resistant isolates from Cameroon were significandy more susceptible to mefloquine and halofantrine in vitro than the chloroquine-sensitive reference clone. Clinical observation, and in vitro confirmation, of chloroquine-resistant falciparum malaria in these indigenous children from Cameroon, and the current socio-economic condition in West Africa, underscore the need for pragmatic health management policies for efficient use of alternative antimalarial dnigs in controlling drug resistant Plasmodium falciparum in the region. This observation of reversal of chloroquine resistance in isolates of P. falciparum obtained from West Africa, and a previous report on clones obtained from south-east Asia and South America, suggest that the mechanism(s) of resistance to chloroquine may be identical in resistant parasites from the 3 continents. © Oxford University Press.
Authors & Co-Authors
Oduola, Ayoade M.J.
United States, New York
Division of Experimental Therapeutics
Kyle, Dennis E.
United States, New York
Division of Experimental Therapeutics
United States, Silver Spring
Walter Reed Army Institute of Research
Gerena, Lucia
United States, New York
Division of Experimental Therapeutics
Cameroon
Medical Research Station
Milhous, Wilbur K.
United States, New York
Division of Experimental Therapeutics
Statistics
Citations: 26
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/0035-9203(89)90482-3
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Multi-countries
Cameroon