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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Plasmodium falciparum Accompanied the Human Expansion out of Africa
Current Biology, Volume 20, No. 14, Year 2010
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Description
Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 million cases of malaria every year, with a further 1.4 billion people at risk of infection [1-3]. Little is known about the genetic makeup of P. falciparum populations, despite variation in genetic diversity being a key factor in morbidity, mortality, and the success of malaria control initiatives. Here we analyze a worldwide sample of 519 P. falciparum isolates sequenced for two housekeeping genes (63 single nucleotide polymorphisms from around 5000 nucleotides per isolate). We observe a strong negative correlation between within-population genetic diversity and geographic distance from sub-Saharan Africa (R 2 = 0.95) over Africa, Asia, and Oceania. In contrast, regional variation in transmission intensity seems to have had a negligible impact on the distribution of genetic diversity. The striking geographic patterns of isolation by distance observed in P. falciparum mirror the ones previously documented in humans [4-7] and point to a joint sub-Saharan African origin between the parasite and its host. Age estimates for the expansion of P. falciparum further support that anatomically modern humans were infected prior to their exit out of Africa and carried the parasite along during their colonization of the world. © 2010 Elsevier Ltd.
Authors & Co-Authors
Tanabe, Kazuyuki
Japan, Suita
Osaka University
Mita, T.
Japan, Tokyo
Tokyo Women's Medical University
Jombart, Thibaut
United Kingdom, London
Medical Research Council
Eriksson, Anders
United Kingdom, Cambridge
University of Cambridge
Palacpac, Nirianne Marie Q.
Japan, Suita
Osaka University
Ranford-Cartwright, Lisa C.
United Kingdom, Glasgow
University of Glasgow
Sakihama, Naoko
Japan, Suita
Osaka University
Ohmae, Hiroshi
Japan, Tokyo
National Institute of Infectious Diseases
Nakamura, Masatoshi
Japan, Shimotsuga District
Dokkyo Medical University
Ferreira, Marcelo Urbano
Brazil, Sao Paulo
Universidade de São Paulo
Escalante, Ananías A.
United States, Tempe
Arizona State University
Prugnolle, Franck
France, Montpellier
Ird Centre de Montpellier
Bjǒrkman, Anders B.
Sweden, Stockholm
Karolinska Institutet
Färnert, Anna
Sweden, Stockholm
Karolinska Institutet
Kaneko, Akira
Sweden, Stockholm
Karolinska Institutet
Japan, Nagasaki
Nagasaki University
Horii, Toshihiro
Japan, Suita
Osaka University
Manica, Andrea
United Kingdom, Cambridge
University of Cambridge
Kishino, Hirohisa
Japan, Tokyo
The University of Tokyo
Balloux, François
United Kingdom, London
Medical Research Council
Statistics
Citations: 105
Authors: 19
Affiliations: 13
Identifiers
Doi:
10.1016/j.cub.2010.05.053
ISSN:
09609822
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study