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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Multiple Method Comparison: Statistical Model Using Percentage Similarity
Cytometry Part B - Clinical Cytometry, Volume 54, No. 1, Year 2003
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Description
Background: Method comparison typically determines how well two methods agree. This is usually performed using the difference plot model, which measures absolute differences between two methods. This is often not applicable to data with wide ranges of absolute values. An alternative model is introduced that simplifies comparisons specifically for multiple methods compared to a gold standard. Methods: The average between a new method and the gold standard is represented as a percentage of the gold standard. This is interpreted as a percentage similarity value and accommodates wide ranges of data. The representation of the percentage similarity values in a histogram format highlights the accuracy and precision of several compared methods to a gold standard. The calculation of a coefficient of variation further defines agreement between methods. Results: Percentage similarity histograms of several new methods can be compared to a gold standard simultaneously, and the comparison easily visualized through use of a single 100% similarity reference line drawn common to all plots. Conclusion. This simple method of comparison would be particularly useful for multiple method comparison and is especially applicable for centers collating for external quality assessment or assurance programs to demonstrate differences in results between laboratories. © 2003 Wiley-Liss, Inc.
Authors & Co-Authors
Scott, Lesley Erica
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
South Africa, Johannesburg
University of the Witwatersrand
Galpin, Jacqueline Suzanne
South Africa, Johannesburg
University of the Witwatersrand
Glencross, Deborah Kim
Unknown Affiliation
Statistics
Citations: 103
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1002/cyto.b.10016
ISSN:
15524949
Study Approach
Systematic review