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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nevirapine resistance in women and infants after first versus repeated use of single-dose nevirapine for prevention of HIV-1 vertical transmission
Journal of Infectious Diseases, Volume 198, No. 4, Year 2008
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Description
Single-dose (SD) nevirapine (NVP) significantly reduces mother-to-child transmission of human immunodeficiency virus (HIV). We analyzed NVP resistance after receipt of SDNVP in 57 previously SD NVP-naive women, in 34 SD NVP-experienced women, and in 17 HIV-infected infants. The proportion of women infected with variants with resistance mutations, the types of mutations detected, and the frequency and level of K103N were similar in the two groups ofwomenat 6 weeks and 6 months post partum. NVP resistance was detected in a similar proportion of infants born to SD NVP-naive versus SD NVP-experienced women. Repeated use of SD NVP to prevent HIV transmission does not appear to influence NVP resistance. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Flys, Tamara S.
United States, Baltimore
Johns Hopkins School of Medicine
McConnell, Michelle S.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Matovu, Flavia Kiweewa
Uganda, Kampala
Makerere University
Church, Jessica D.
United States, Baltimore
Johns Hopkins School of Medicine
Bagenda, Danstan S.
Uganda, Kampala
Makerere University
Uganda, Kampala
Makerere University School of Public Health
Khaki, Leila
United States, Baltimore
Johns Hopkins School of Medicine
Bakaki, Paul M.
Uganda, Kampala
Makerere University
United States, Cleveland
Case Western Reserve University
Thigpen, Michael C.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Eure, Chineta R.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Fowler, Mary Glenn
United States, Baltimore
Johns Hopkins School of Medicine
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Eshleman, Susan H.
United States, Baltimore
Johns Hopkins School of Medicine
United States, Baltimore
Johns Hopkins Medical Institutions
Statistics
Citations: 27
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1086/590160
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Participants Gender
Female