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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Comparing the understanding of subjects receiving a candidate malaria vaccine in the United States and Mali
American Journal of Tropical Medicine and Hygiene, Volume 83, No. 4, Year 2010
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Description
Initial responses to questionnaires used to assess participants' understanding of informed consent for malaria vaccine trials conducted in the United States and Mali were tallied. Total scores were analyzed by age, sex, literacy (if known), and location. Ninety-two percent (92%) of answers by United States participants and 85% of answers by Malian participants were correct. Questions more likely to be answered incorrectly in Mali related to risk, and to the type of vaccine. For adult participants, independent predictors of higher scores were younger age and female sex in the United States, and male sex in Mali. Scores in the United States were higher than in Mali (P = 0.005). Despite this difference participants at both sites were well informed overall. Although interpretation must be qualified because questionnaires were not intended as research tools and were not standardized among sites, these results do not support concerns about systematic low understanding among research participants in developing versus developed countries. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Ellis, Ruth D.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Sagara, Issaka
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Durbin, Anna P.
United States, Washington
Johns Hopkins Center for Immunization Research
Dicko, Alassane A.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Shaffer, Donna
United States, Washington
Johns Hopkins Center for Immunization Research
Miller, Louis H.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Assadou, Mahamadoun Hamady
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Kone, Mamady
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Kamate, Beh
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Guindo, Ousmane
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Fay, Michael P.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Diallo, Dapa Aly
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Emanuel, Ezekiel J.
United States, Bethesda
National Institutes of Health Nih
Millum, Joseph
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 23
Authors: 15
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2010.10-0062
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Mali
Participants Gender
Male
Female