Publication Details

AFRICAN RESEARCH NEXUS

SHINING A SPOTLIGHT ON AFRICAN RESEARCH

immunology and microbiology

Comparing the understanding of subjects receiving a candidate malaria vaccine in the United States and Mali

American Journal of Tropical Medicine and Hygiene, Volume 83, No. 4, Year 2010

Initial responses to questionnaires used to assess participants' understanding of informed consent for malaria vaccine trials conducted in the United States and Mali were tallied. Total scores were analyzed by age, sex, literacy (if known), and location. Ninety-two percent (92%) of answers by United States participants and 85% of answers by Malian participants were correct. Questions more likely to be answered incorrectly in Mali related to risk, and to the type of vaccine. For adult participants, independent predictors of higher scores were younger age and female sex in the United States, and male sex in Mali. Scores in the United States were higher than in Mali (P = 0.005). Despite this difference participants at both sites were well informed overall. Although interpretation must be qualified because questionnaires were not intended as research tools and were not standardized among sites, these results do not support concerns about systematic low understanding among research participants in developing versus developed countries. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Statistics
Citations: 23
Authors: 15
Affiliations: 4
Identifiers
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Mali
Participants Gender
Male
Female