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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The correlation between asthma control and health status: The GOAL study
European Respiratory Journal, Volume 29, No. 1, Year 2007
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Description
The present study examined the association between guideline-derived asthma control and health-related quality of life, assessed using the Asthma Quality of Life Questionnaire (AQLQ), in patients with uncontrolled asthma whose treatment was directed towards achieving the highest possible level of control. The present randomised, double-blind, parallel-group study compared the efficacy of fluticasone propionate (FIR) and salmeterol/fluticasone propionate combination (SFC) in achieving two composite, guideline-derived measures of control: total control (TC) and well-controlled (WC) asthma. Not achieving these levels was classed as not well-controlled (NWC). Doses were augmented until patients achieved TC or reached the maximum dose. This dose was maintained for the remainder of the study. AQLQ was assessed at baseline and at each clinic visit. AQLQ scores improved throughout the study, reaching near-maximal levels in patients achieving TC and WC, and 52-week mean scores in the three control groups were statistically significantly different. Clinically meaningful improvements (mean change from baseline) were: TC group (SFC 1.9, FP 1.8), WC (SFC 1.5, FP 1.5) and NWC (SFC 1.0, FP 0.9). In conclusion, the treatment aimed at controlling asthma improves the health-related quality of life to levels approaching normal. The difference in Asthma Quality of Life Questionnaire scores between total control and well-controlled confirms that patients distinguish even between these high levels of control. Copyright © ERS Journals Ltd 2007.
Authors & Co-Authors
Bateman, E. D.
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
University of Cape Town Lung Institute
Bousquet, Jean J.
France, Montpellier
Hopital Arnaud de Villeneuve
Keech, M. L.
United Kingdom, Brentford
Glaxosmithkline Plc.
Busse, William Walter
United States, Madison
University of Wisconsin School of Medicine and Public Health
Clark, Timothy J.H.
United Kingdom, London
Imperial College London
Pedersen, Soøren Erik
Denmark, Odense
Syddansk Universitet
Statistics
Citations: 161
Authors: 6
Affiliations: 7
Identifiers
Doi:
10.1183/09031936.00128505
ISSN:
09031936
Research Areas
Disability
Health System And Policy