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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania
Wiener Klinische Wochenschrift, Volume 128, No. 15-16, Year 2016
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Description
African tick bite fever is an emerging infectious disease among travellers caused by the pathogen Rickettsia africae. Most travel-associated cases have been reported from countries in southern Africa. So far it has rarely been reported among travellers to eastern Africa and our patient is one of the first described cases imported from Tanzania. A woman presented with fever, chills, headache, myalgia and a rickettsial eschar on her ankle after returning from Tanzania. The diagnosis of African tick bite fever is often based on clinical grounds due to a lack of reliable diagnostic tests at commencement of symptoms. In this patient direct molecular detection of R. africae was performed by PCR from a sample obtained non-invasively with a swab from the rickettsial eschar. A positive PCR result was achieved although the patient had already started antibiotic treatment with doxycycline. In conclusion, this non-invasive method enables early diagnosis of African tick bite fever by direct molecular detection of R. africae and might improve the management of undifferentiated fever in travellers from Africa. © 2016, The Author(s).
Authors & Co-Authors
Harrison, Nicole
Austria, Vienna
Medizinische Universität Wien
Burgmann, H.
Austria, Vienna
Medizinische Universität Wien
Forstner, Christina
Austria, Vienna
Medizinische Universität Wien
Germany, Jena
Universitätsklinikum Jena Und Medizinische Fakultät
Ramharter, Michael
Austria, Vienna
Medizinische Universität Wien
Germany, Tubingen
Eberhard Karls Universität Tübingen
Statistics
Citations: 11
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1007/s00508-016-1047-0
ISSN:
00435325
Research Areas
Health System And Policy
Study Locations
Tanzania
Participants Gender
Female